Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 902994..903586 Replicon chromosome
Accession NZ_CP098757
Organism Klebsiella oxytoca strain AHC-6

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NDX50_RS04380 Protein ID WP_016808034.1
Coordinates 902994..903368 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2J4YM08
Locus tag NDX50_RS04385 Protein ID WP_004105957.1
Coordinates 903365..903586 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDX50_RS04360 (NDX50_04355) 898343..899686 - 1344 WP_004105949.1 glycoside-pentoside-hexuronide (GPH):cation symporter -
NDX50_RS04365 (NDX50_04360) 899794..900660 + 867 WP_004105950.1 AraC family transcriptional regulator -
NDX50_RS04370 (NDX50_04365) 900789..902432 + 1644 WP_004115710.1 glycoside hydrolase family 43 protein -
NDX50_RS04375 (NDX50_04370) 902511..903014 + 504 WP_224313900.1 M48 family metallopeptidase -
NDX50_RS04380 (NDX50_04375) 902994..903368 - 375 WP_016808034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NDX50_RS04385 (NDX50_04380) 903365..903586 - 222 WP_004105957.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NDX50_RS04390 (NDX50_04385) 903746..904735 + 990 WP_023321666.1 Gfo/Idh/MocA family oxidoreductase -
NDX50_RS04395 (NDX50_04390) 904986..905954 + 969 WP_004115718.1 TerC family protein -
NDX50_RS04400 (NDX50_04395) 906209..907456 + 1248 WP_064397182.1 serine/threonine transporter SstT -
NDX50_RS04405 (NDX50_04400) 907471..908025 - 555 WP_004105965.1 YgjV family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13835.89 Da        Isoelectric Point: 6.0752

>T247997 WP_016808034.1 NZ_CP098757:c903368-902994 [Klebsiella oxytoca]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHCEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8185.19 Da        Isoelectric Point: 5.7996

>AT247997 WP_004105957.1 NZ_CP098757:c903586-903365 [Klebsiella oxytoca]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4YM08

References