Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 678792..679449 Replicon chromosome
Accession NZ_CP098757
Organism Klebsiella oxytoca strain AHC-6

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag NDX50_RS03315 Protein ID WP_004105559.1
Coordinates 678792..679202 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag NDX50_RS03320 Protein ID WP_004105561.1
Coordinates 679183..679449 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDX50_RS03295 (NDX50_03290) 674769..676502 - 1734 WP_024274698.1 single-stranded-DNA-specific exonuclease RecJ -
NDX50_RS03300 (NDX50_03295) 676508..677221 - 714 WP_004105554.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NDX50_RS03305 (NDX50_03300) 677244..678140 - 897 WP_064397254.1 site-specific tyrosine recombinase XerD -
NDX50_RS03310 (NDX50_03305) 678262..678783 + 522 WP_004105557.1 flavodoxin FldB -
NDX50_RS03315 (NDX50_03310) 678792..679202 - 411 WP_004105559.1 protein YgfX Toxin
NDX50_RS03320 (NDX50_03315) 679183..679449 - 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
NDX50_RS03325 (NDX50_03320) 679693..680676 + 984 WP_064397252.1 tRNA-modifying protein YgfZ -
NDX50_RS03330 (NDX50_03325) 680852..683650 + 2799 WP_064397250.1 transcriptional regulator DagR -
NDX50_RS03335 (NDX50_03330) 683771..684196 + 426 WP_004124962.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T247996 WP_004105559.1 NZ_CP098757:c679202-678792 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT247996 WP_004105561.1 NZ_CP098757:c679449-679183 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References