Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 610111..610764 Replicon chromosome
Accession NZ_CP098755
Organism Brevibacillus sp. BB3-R1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NDK47_RS03160 Protein ID WP_198828445.1
Coordinates 610414..610764 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NDK47_RS03155 Protein ID WP_251873496.1
Coordinates 610111..610410 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDK47_RS03130 (NDK47_03130) 605235..605642 + 408 WP_251875941.1 holo-ACP synthase -
NDK47_RS03135 (NDK47_03135) 605888..606922 + 1035 WP_251873492.1 DUF4367 domain-containing protein -
NDK47_RS03140 (NDK47_03140) 607180..607548 - 369 WP_251873493.1 hypothetical protein -
NDK47_RS03145 (NDK47_03145) 608297..608737 + 441 WP_251873494.1 hypothetical protein -
NDK47_RS03150 (NDK47_03150) 608741..609943 + 1203 WP_251873495.1 alanine racemase -
NDK47_RS03155 (NDK47_03155) 610111..610410 + 300 WP_251873496.1 CopG family ribbon-helix-helix protein Antitoxin
NDK47_RS03160 (NDK47_03160) 610414..610764 + 351 WP_198828445.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NDK47_RS03165 (NDK47_03165) 610923..611330 + 408 WP_251873497.1 anti-sigma regulatory factor -
NDK47_RS03170 (NDK47_03170) 611355..612353 + 999 WP_251873498.1 SpoIIE family protein phosphatase -
NDK47_RS03175 (NDK47_03175) 612376..612702 + 327 WP_251873499.1 STAS domain-containing protein -
NDK47_RS03180 (NDK47_03180) 612702..613196 + 495 WP_251873500.1 anti-sigma B factor RsbW -
NDK47_RS03185 (NDK47_03185) 613165..613953 + 789 WP_251873501.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-52)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12961.98 Da        Isoelectric Point: 4.8553

>T247995 WP_198828445.1 NZ_CP098755:610414-610764 [Brevibacillus sp. BB3-R1]
VIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKMYGFDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMERVNESLQISLGIIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11302.24 Da        Isoelectric Point: 10.3594

>AT247995 WP_251873496.1 NZ_CP098755:610111-610410 [Brevibacillus sp. BB3-R1]
MVGGGFVLSKSNTKRIMISLPHHLLQEVDGVIQKEKSNRSEFIRQAMHLYLKERKKRAIRETMQKGYMEMAKINLKMASE
AFGAEEEADHTLVRLVSGV

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References