Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 939781..940232 Replicon chromosome
Accession NZ_CP098754
Organism Brachyspira pilosicoli strain MEI4028

Toxin (Protein)


Gene name hicA Uniprot ID J9UUS4
Locus tag NEH99_RS04085 Protein ID WP_014933300.1
Coordinates 939781..940014 (-) Length 78 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID D8IB43
Locus tag NEH99_RS04090 Protein ID WP_013243321.1
Coordinates 940011..940232 (-) Length 74 a.a.

Genomic Context

NEH99_RS04075NEH99_RS04080NEH99_RS04110NEH99_RS04115NEH99_RS04085NEH99_RS04090NEH99_RS04095NEH99_RS04100NEH99_RS04105
Location: 935421..937838 (2418 bp)
Type: Others
Protein ID: WP_013243318.1
Location: 937844..939697 (1854 bp)
Type: Others
Protein ID: WP_013243319.1
Location: 943131..943589 (459 bp)
Type: Others
Protein ID: WP_013243324.1
Location: 943726..944871 (1146 bp)
Type: Others
Protein ID: WP_013243325.1
Location: 939781..940014 (234 bp)
Type: Toxin
Protein ID: WP_014933300.1
Location: 940011..940232 (222 bp)
Type: Antitoxin
Protein ID: WP_013243321.1
Location: 940286..941719 (1434 bp)
Type: Others
Protein ID: WP_284603203.1
Location: 942005..942340 (336 bp)
Type: Others
Protein ID: WP_232472976.1
Location: 942419..942820 (402 bp)
Type: Others
Protein ID: WP_284603204.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NEH99_RS04075 (NEH99_04070)935421..937838+2418WP_013243318.1PBP1A family penicillin-binding protein-
NEH99_RS04080 (NEH99_04075)937844..939697+1854WP_013243319.1conjugal transfer protein TraB-
NEH99_RS04085 (NEH99_04080)939781..940014-234WP_014933300.1type II toxin-antitoxin system HicA family toxinToxin
NEH99_RS04090 (NEH99_04085)940011..940232-222WP_013243321.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
NEH99_RS04095 (NEH99_04090)940286..941719-1434WP_284603203.1hypothetical protein-
NEH99_RS04100 (NEH99_04095)942005..942340-336WP_232472976.1Hsp20/alpha crystallin family protein-
NEH99_RS04105 (NEH99_04100)942419..942820-402WP_284603204.1Hsp20/alpha crystallin family protein-
NEH99_RS04110 (NEH99_04105)943131..943589+459WP_013243324.1large conductance mechanosensitive channel protein MscL-
NEH99_RS04115 (NEH99_04110)943726..944871+1146WP_013243325.1alanine--glyoxylate aminotransferase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-70)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 9027.69 Da        Isoelectric Point: 10.1753

>T247994 WP_014933300.1 NZ_CP098754:c940014-939781 [Brachyspira pilosicoli]
MSKLILKDAKTIEKLLFLLGFVKQRQKGSHAFYKHEDGRCTVIPFHSSKVISRPLMRKILNEINLDVEEYNNLIEKI

Download         Length: 234 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8551.86 Da        Isoelectric Point: 4.3348

>AT247994 WP_013243321.1 NZ_CP098754:c940232-940011 [Brachyspira pilosicoli]
MKKKFFAYIEYDKETNVYVGYIPSIVGAHTQADTLEELHIKLKEVLDLCLEEMDSEEKKTIPEFVKVEEIELV

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBJ9UUS4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A381A9L8

References