247991

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 941949..942400 Replicon chromosome
Accession NZ_CP098751
Organism Brachyspira pilosicoli strain ZH1145

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NEI05_RS04145 Protein ID WP_041747496.1
Coordinates 941949..942182 (-) Length 78 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID D8IB43
Locus tag NEI05_RS04150 Protein ID WP_013243321.1
Coordinates 942179..942400 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NEI05_RS04135 (NEI05_04130) 937588..940005 + 2418 WP_013243318.1 PBP1A family penicillin-binding protein -
NEI05_RS04140 (NEI05_04135) 940012..941865 + 1854 WP_284635662.1 conjugal transfer protein TraB -
NEI05_RS04145 (NEI05_04140) 941949..942182 - 234 WP_041747496.1 type II toxin-antitoxin system HicA family toxin Toxin
NEI05_RS04150 (NEI05_04145) 942179..942400 - 222 WP_013243321.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NEI05_RS04155 (NEI05_04150) 942674..943009 - 336 WP_232471225.1 Hsp20/alpha crystallin family protein -
NEI05_RS04160 (NEI05_04155) 943100..943501 - 402 WP_157143032.1 Hsp20/alpha crystallin family protein -
NEI05_RS04165 (NEI05_04160) 943812..944270 + 459 WP_014936232.1 large conductance mechanosensitive channel protein MscL -
NEI05_RS04170 (NEI05_04165) 944405..945550 + 1146 WP_219708991.1 alanine--glyoxylate aminotransferase family protein -
NEI05_RS04175 (NEI05_04170) 945681..947285 + 1605 WP_013243326.1 phosphoglycerate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-70)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 9036.71 Da        Isoelectric Point: 10.1753

>T247991 WP_041747496.1 NZ_CP098751:c942182-941949 [Brachyspira pilosicoli]
MSKLILKDAKTIEKLLFLLGFVKHRQKGSHAFYKHEDGRCTVIPFHSSKVISRPLMRKILNEINLDVEEYNNLIEKI

Download         Length: 234 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8551.86 Da        Isoelectric Point: 4.3348

>AT247991 WP_013243321.1 NZ_CP098751:c942400-942179 [Brachyspira pilosicoli]
MKKKFFAYIEYDKETNVYVGYIPSIVGAHTQADTLEELHIKLKEVLDLCLEEMDSEEKKTIPEFVKVEEIELV

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A381A9L8

References