Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 969712..970163 Replicon chromosome
Accession NZ_CP098750
Organism Brachyspira pilosicoli strain ZH1243

Toxin (Protein)


Gene name hicA Uniprot ID J9UUS4
Locus tag NEI03_RS04345 Protein ID WP_014933300.1
Coordinates 969712..969945 (-) Length 78 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID D8IB43
Locus tag NEI03_RS04350 Protein ID WP_013243321.1
Coordinates 969942..970163 (-) Length 74 a.a.

Genomic Context

NEI03_RS04335NEI03_RS04340NEI03_RS04365NEI03_RS04370NEI03_RS04375NEI03_RS04345NEI03_RS04350NEI03_RS04355NEI03_RS04360
Location: 965352..967769 (2418 bp)
Type: Others
Protein ID: WP_013243318.1
Location: 967775..969628 (1854 bp)
Type: Others
Protein ID: WP_013243319.1
Location: 971575..972033 (459 bp)
Type: Others
Protein ID: WP_284622096.1
Location: 972169..973314 (1146 bp)
Type: Others
Protein ID: WP_101503636.1
Location: 973446..975050 (1605 bp)
Type: Others
Protein ID: WP_013243326.1
Location: 969712..969945 (234 bp)
Type: Toxin
Protein ID: WP_014933300.1
Location: 969942..970163 (222 bp)
Type: Antitoxin
Protein ID: WP_013243321.1
Location: 970437..970772 (336 bp)
Type: Others
Protein ID: WP_284622177.1
Location: 970863..971264 (402 bp)
Type: Others
Protein ID: WP_157146546.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NEI03_RS04335 (NEI03_04330)965352..967769+2418WP_013243318.1PBP1A family penicillin-binding protein-
NEI03_RS04340 (NEI03_04335)967775..969628+1854WP_013243319.1conjugal transfer protein TraB-
NEI03_RS04345 (NEI03_04340)969712..969945-234WP_014933300.1type II toxin-antitoxin system HicA family toxinToxin
NEI03_RS04350 (NEI03_04345)969942..970163-222WP_013243321.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
NEI03_RS04355 (NEI03_04350)970437..970772-336WP_284622177.1Hsp20/alpha crystallin family protein-
NEI03_RS04360 (NEI03_04355)970863..971264-402WP_157146546.1Hsp20/alpha crystallin family protein-
NEI03_RS04365 (NEI03_04360)971575..972033+459WP_284622096.1large conductance mechanosensitive channel protein MscL-
NEI03_RS04370 (NEI03_04365)972169..973314+1146WP_101503636.1alanine--glyoxylate aminotransferase family protein-
NEI03_RS04375 (NEI03_04370)973446..975050+1605WP_013243326.1phosphoglycerate dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-70)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 9027.69 Da        Isoelectric Point: 10.1753

>T247990 WP_014933300.1 NZ_CP098750:c969945-969712 [Brachyspira pilosicoli]
MSKLILKDAKTIEKLLFLLGFVKQRQKGSHAFYKHEDGRCTVIPFHSSKVISRPLMRKILNEINLDVEEYNNLIEKI

Download         Length: 234 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8551.86 Da        Isoelectric Point: 4.3348

>AT247990 WP_013243321.1 NZ_CP098750:c970163-969942 [Brachyspira pilosicoli]
MKKKFFAYIEYDKETNVYVGYIPSIVGAHTQADTLEELHIKLKEVLDLCLEEMDSEEKKTIPEFVKVEEIELV

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBJ9UUS4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A381A9L8

References