Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 260266..260717 Replicon chromosome
Accession NZ_CP098749
Organism Brachyspira pilosicoli strain ZH1244

Toxin (Protein)


Gene name hicA Uniprot ID J9UUS4
Locus tag NEI00_RS01200 Protein ID WP_014933300.1
Coordinates 260484..260717 (+) Length 78 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID D8IB43
Locus tag NEI00_RS01195 Protein ID WP_013243321.1
Coordinates 260266..260487 (+) Length 74 a.a.

Genomic Context

NEI00_RS01185NEI00_RS01190NEI00_RS01195NEI00_RS01200NEI00_RS01170NEI00_RS01175NEI00_RS01180NEI00_RS01205NEI00_RS01210
Location: 259165..259566 (402 bp)
Type: Others
Protein ID: WP_014933304.1
Location: 259657..259992 (336 bp)
Type: Others
Protein ID: WP_232471225.1
Location: 260266..260487 (222 bp)
Type: Antitoxin
Protein ID: WP_013243321.1
Location: 260484..260717 (234 bp)
Type: Toxin
Protein ID: WP_014933300.1
Location: 255379..256983 (1605 bp)
Type: Others
Protein ID: WP_013243326.1
Location: 257115..258260 (1146 bp)
Type: Others
Protein ID: WP_284621214.1
Location: 258396..258854 (459 bp)
Type: Others
Protein ID: WP_284621215.1
Location: 260801..262654 (1854 bp)
Type: Others
Protein ID: WP_013243319.1
Location: 262661..265078 (2418 bp)
Type: Others
Protein ID: WP_013243318.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NEI00_RS01170 (NEI00_01170)255379..256983-1605WP_013243326.1phosphoglycerate dehydrogenase-
NEI00_RS01175 (NEI00_01175)257115..258260-1146WP_284621214.1alanine--glyoxylate aminotransferase family protein-
NEI00_RS01180 (NEI00_01180)258396..258854-459WP_284621215.1large conductance mechanosensitive channel protein MscL-
NEI00_RS01185 (NEI00_01185)259165..259566+402WP_014933304.1Hsp20/alpha crystallin family protein-
NEI00_RS01190 (NEI00_01190)259657..259992+336WP_232471225.1Hsp20/alpha crystallin family protein-
NEI00_RS01195 (NEI00_01195)260266..260487+222WP_013243321.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
NEI00_RS01200 (NEI00_01200)260484..260717+234WP_014933300.1type II toxin-antitoxin system HicA family toxinToxin
NEI00_RS01205 (NEI00_01205)260801..262654-1854WP_013243319.1conjugal transfer protein TraB-
NEI00_RS01210 (NEI00_01210)262661..265078-2418WP_013243318.1PBP1A family penicillin-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-70)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 9027.69 Da        Isoelectric Point: 10.1753

>T247989 WP_014933300.1 NZ_CP098749:260484-260717 [Brachyspira pilosicoli]
MSKLILKDAKTIEKLLFLLGFVKQRQKGSHAFYKHEDGRCTVIPFHSSKVISRPLMRKILNEINLDVEEYNNLIEKI

Download         Length: 234 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8551.86 Da        Isoelectric Point: 4.3348

>AT247989 WP_013243321.1 NZ_CP098749:260266-260487 [Brachyspira pilosicoli]
MKKKFFAYIEYDKETNVYVGYIPSIVGAHTQADTLEELHIKLKEVLDLCLEEMDSEEKKTIPEFVKVEEIELV

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBJ9UUS4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A381A9L8

References