Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2622699..2623270 Replicon chromosome
Accession NZ_CP098743
Organism Enterococcus faecalis strain M9

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag NDO76_RS12620 Protein ID WP_002360937.1
Coordinates 2622699..2623040 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag NDO76_RS12625 Protein ID WP_002367500.1
Coordinates 2623040..2623270 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDO76_RS12615 (2618714) 2618714..2622328 - 3615 WP_010712913.1 DNA-directed RNA polymerase subunit beta -
NDO76_RS12620 (2622699) 2622699..2623040 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NDO76_RS12625 (2623040) 2623040..2623270 - 231 WP_002367500.1 hypothetical protein Antitoxin
NDO76_RS12630 (2623676) 2623676..2623891 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
NDO76_RS12635 (2624030) 2624030..2625022 + 993 WP_002398510.1 biotin--[acetyl-CoA-carboxylase] ligase -
NDO76_RS12640 (2625189) 2625189..2625827 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
NDO76_RS12645 (2626511) 2626511..2628127 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T247977 WP_002360937.1 NZ_CP098743:c2623040-2622699 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT247977 WP_002367500.1 NZ_CP098743:c2623270-2623040 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References