Detailed information of TA system TA024797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1844823..1845240
• Replicon: chromosome
• Accession: NC_014228
• Organism: Xenorhabdus nematophila ATCC 19061

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: XNC1_RS08245
• Protein ID: WP_013184145.1
• Coordinates: 1844823..1844996 (-)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N1NP74
• Locus tag: XNC1_RS08250
• Protein ID: WP_010847387.1
• Coordinates: 1844986..1845240 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XNC1_RS08225 (XNC1_1936)	1840164..1840748	+	585	WP_143767639.1	manganese efflux pump MntP	-
XNC1_RS08230 (XNC1_1937)	1840858..1841679	-	822	WP_041573672.1	23S rRNA (guanine(745)-N(1))-methyltransferase	-
XNC1_RS08235 (XNC1_1938)	1841963..1843291	-	1329	WP_010847384.1	MFS transporter	-
XNC1_RS08240 (XNC1_1939)	1843300..1844823	-	1524	WP_013184144.1	signal transduction histidine-protein kinase/phosphatase UhpB	-
XNC1_RS08245 (XNC1_1940)	1844823..1844996	-	174	WP_013184145.1	toxin-antitoxin system protein	Toxin
XNC1_RS08250 (XNC1_1941)	1844986..1845240	-	255	WP_010847387.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
XNC1_RS08255 (XNC1_1943)	1845680..1846060	+	381	WP_113967564.1	transposase	-
XNC1_RS08260 (XNC1_1944)	1846066..1846683	-	618	WP_010847389.1	transcriptional regulator UhpA	-
XNC1_RS08265 (XNC1_1945)	1846825..1848201	-	1377	WP_010847390.1	hexose-6-phosphate:phosphate antiporter	-
XNC1_RS08270 (XNC1_1947)	1848808..1849143	-	336	WP_013184149.1	hypothetical protein	-
XNC1_RS08275 (XNC1_1948)	1849529..1850218	+	690	WP_010847392.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-74)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6973.13 Da
• Isoelectric Point: 10.1541

>T24797 WP_013184145.1 NC_014228:c1844996-1844823 [Xenorhabdus nematophila ATCC 19061]
MIFNIEFDERAVKEWQKLDNSIREQFKKKLKKLQKNPYIEPARLHGDLACFLRNFSF

Nucleotide

• Length: 174 bp

>T24797 NC_014228:c1844996-1844823 [Xenorhabdus nematophila ATCC 19061]
ATGATATTTAATATCGAGTTTGACGAACGCGCGGTAAAAGAATGGCAAAAGCTGGATAACAGCATTCGTGAACAGTTTAA
AAAGAAGCTGAAAAAGTTACAGAAAAACCCTTATATCGAGCCTGCCAGACTACATGGCGATTTAGCGTGTTTTCTGAGGA
ATTTTTCTTTTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9831.21 Da
• Isoelectric Point: 4.7025

>AT24797 WP_010847387.1 NC_014228:c1845240-1844986 [Xenorhabdus nematophila ATCC 19061]
MSTIQIRVDEELKKSAYQAFDKLNLSPSDAMRLFLRYVAEHEKLPFTEVSVMVAEHDEDEDILDVVRDRLKNPAKRIRVN
LDDI

Nucleotide

• Length: 255 bp

>AT24797 NC_014228:c1845240-1844986 [Xenorhabdus nematophila ATCC 19061]
ATGAGCACCATCCAAATAAGAGTAGATGAAGAGCTTAAGAAAAGTGCATATCAGGCATTTGATAAGCTGAATCTGTCCCC
TTCTGATGCAATGCGACTCTTCCTGCGTTATGTGGCAGAACATGAAAAGCTACCATTTACTGAGGTATCGGTGATGGTTG
CAGAGCACGATGAAGATGAAGATATTCTGGATGTAGTACGCGATCGCCTAAAGAATCCTGCCAAACGAATCCGGGTAAAT
CTCGATGATATTTAA

Structures

Antitoxin

• AlphaFold DB: N1NP74