Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 261..904 Replicon plasmid unnamed1
Accession NZ_CP098742
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain HJL222

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag NCG87_RS23375 Protein ID WP_001034044.1
Coordinates 488..904 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag NCG87_RS23370 Protein ID WP_001261286.1
Coordinates 261..491 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCG87_RS23370 (261) 261..491 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NCG87_RS23375 (488) 488..904 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
NCG87_RS23380 (979) 979..2544 + 1566 WP_001128474.1 AAA family ATPase -
NCG87_RS23385 (2529) 2529..3551 + 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD / tet(B) iutA / iucD / iucC / iucB / iucA 1..109442 109442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T247964 WP_001034044.1 NZ_CP098742:488-904 [Salmonella enterica subsp. enterica serovar Typhimurium]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT247964 WP_001261286.1 NZ_CP098742:261-491 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References