247963

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 4696747..4697269 Replicon chromosome
Accession NZ_CP098741
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain HJL222

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NCG87_RS22810 Protein ID WP_000221343.1
Coordinates 4696747..4697031 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NCG87_RS22815 Protein ID WP_000885424.1
Coordinates 4697021..4697269 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCG87_RS22790 (4692822) 4692822..4694330 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
NCG87_RS22795 (4694375) 4694375..4694863 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NCG87_RS22800 (4695056) 4695056..4696135 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NCG87_RS22805 (4696187) 4696187..4696576 - 390 WP_000194089.1 RidA family protein -
NCG87_RS22810 (4696747) 4696747..4697031 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NCG87_RS22815 (4697021) 4697021..4697269 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NCG87_RS22820 (4697421) 4697421..4697636 + 216 WP_000206207.1 hypothetical protein -
NCG87_RS22825 (4697626) 4697626..4697958 + 333 WP_000253154.1 DUF1493 family protein -
NCG87_RS22830 (4698101) 4698101..4699009 + 909 WP_010989018.1 hypothetical protein -
NCG87_RS22835 (4699065) 4699065..4699779 - 715 Protein_4446 helix-turn-helix domain-containing protein -
NCG87_RS22840 (4700587) 4700587..4702053 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T247963 WP_000221343.1 NZ_CP098741:c4697031-4696747 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT247963 WP_000885424.1 NZ_CP098741:c4697269-4697021 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References