Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3641175..3641795 Replicon chromosome
Accession NZ_CP098741
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain HJL222

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NCG87_RS17505 Protein ID WP_001280991.1
Coordinates 3641175..3641393 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NCG87_RS17510 Protein ID WP_000344807.1
Coordinates 3641421..3641795 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCG87_RS17465 (3636399) 3636399..3636968 + 570 WP_000779803.1 YbaY family lipoprotein -
NCG87_RS17470 (3637001) 3637001..3637390 - 390 WP_000961285.1 MGMT family protein -
NCG87_RS17480 (3637621) 3637621..3639171 - 1551 WP_000213139.1 EAL domain-containing protein -
NCG87_RS17485 (3639396) 3639396..3639656 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NCG87_RS17490 (3639662) 3639662..3639802 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NCG87_RS17495 (3639858) 3639858..3640328 - 471 WP_000136181.1 YlaC family protein -
NCG87_RS17500 (3640445) 3640445..3640996 - 552 WP_001278792.1 maltose O-acetyltransferase -
NCG87_RS17505 (3641175) 3641175..3641393 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NCG87_RS17510 (3641421) 3641421..3641795 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NCG87_RS17515 (3642291) 3642291..3645440 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NCG87_RS17520 (3645463) 3645463..3646656 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T247962 WP_001280991.1 NZ_CP098741:c3641393-3641175 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT247962 WP_000344807.1 NZ_CP098741:c3641795-3641421 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References