Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2999868..3000444 Replicon chromosome
Accession NZ_CP098741
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain HJL222

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag NCG87_RS14425 Protein ID WP_001131963.1
Coordinates 2999868..3000155 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag NCG87_RS14430 Protein ID WP_000063142.1
Coordinates 3000142..3000444 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCG87_RS14415 (2994978) 2994978..2998487 - 3510 WP_001043485.1 type I restriction-modification system endonuclease -
NCG87_RS14420 (2998685) 2998685..2999599 + 915 WP_000290512.1 restriction endonuclease -
NCG87_RS14425 (2999868) 2999868..3000155 + 288 WP_001131963.1 BrnT family toxin Toxin
NCG87_RS14430 (3000142) 3000142..3000444 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
NCG87_RS14435 (3000519) 3000519..3001475 - 957 WP_000187839.1 GTPase -
NCG87_RS14440 (3001486) 3001486..3001689 - 204 WP_000460616.1 YbdD/YjiX family protein -
NCG87_RS14445 (3001784) 3001784..3003934 - 2151 WP_000379927.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T247959 WP_001131963.1 NZ_CP098741:2999868-3000155 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT247959 WP_000063142.1 NZ_CP098741:3000142-3000444 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References