247958

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2905667..2906183 Replicon chromosome
Accession NZ_CP098741
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain HJL222

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NCG87_RS14025 Protein ID WP_000220578.1
Coordinates 2905899..2906183 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NCG87_RS14020 Protein ID WP_000212724.1
Coordinates 2905667..2905909 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCG87_RS14000 (2900687) 2900687..2901820 + 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -
NCG87_RS14005 (2901804) 2901804..2902922 + 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NCG87_RS14010 (2902919) 2902919..2903659 + 741 WP_000779263.1 KDGP aldolase family protein -
NCG87_RS14015 (2903676) 2903676..2905589 + 1914 WP_001212137.1 BglG family transcription antiterminator -
NCG87_RS14020 (2905667) 2905667..2905909 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NCG87_RS14025 (2905899) 2905899..2906183 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NCG87_RS14030 (2906187) 2906187..2906651 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NCG87_RS14035 (2906772) 2906772..2908910 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NCG87_RS14040 (2909319) 2909319..2910971 - 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T247958 WP_000220578.1 NZ_CP098741:2905899-2906183 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT247958 WP_000212724.1 NZ_CP098741:2905667-2905909 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References