Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2051239..2051999 Replicon chromosome
Accession NZ_CP098741
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain HJL222

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag NCG87_RS09995 Protein ID WP_000533909.1
Coordinates 2051239..2051724 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag NCG87_RS10000 Protein ID WP_000965886.1
Coordinates 2051712..2051999 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCG87_RS09965 (2046309) 2046309..2046971 + 663 WP_000747548.1 OmpA family lipoprotein -
NCG87_RS09970 (2047190) 2047190..2048164 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
NCG87_RS09975 (2048214) 2048214..2048924 - 711 WP_000190524.1 DUF3053 domain-containing protein -
NCG87_RS09980 (2049363) 2049363..2049653 + 291 WP_000455790.1 HTH-type transcriptional regulator -
NCG87_RS09985 (2049942) 2049942..2050154 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NCG87_RS09990 (2050328) 2050328..2050867 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
NCG87_RS09995 (2051239) 2051239..2051724 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
NCG87_RS10000 (2051712) 2051712..2051999 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
NCG87_RS10005 (2052177) 2052177..2052644 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
NCG87_RS10010 (2052816) 2052816..2053091 - 276 Protein_1953 IS3 family transposase -
NCG87_RS10015 (2053273) 2053273..2055342 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
NCG87_RS10020 (2055352) 2055352..2056263 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
NCG87_RS10025 (2056402) 2056402..2056704 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T247954 WP_000533909.1 NZ_CP098741:c2051724-2051239 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT247954 WP_000965886.1 NZ_CP098741:c2051999-2051712 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References