Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2504950..2505475 Replicon chromosome
Accession NZ_CP098740
Organism Streptomyces drozdowiczii strain MDA8-470

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NEH16_RS11085 Protein ID WP_265541736.1
Coordinates 2505212..2505475 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NEH16_RS11080 Protein ID WP_265541734.1
Coordinates 2504950..2505219 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NEH16_RS11055 (NEH16_11035) 2500372..2501187 - 816 WP_265541722.1 SDR family oxidoreductase -
NEH16_RS11060 (NEH16_11040) 2501348..2501932 + 585 WP_265541724.1 helix-turn-helix domain-containing protein -
NEH16_RS11065 (NEH16_11045) 2501973..2502596 + 624 WP_265541725.1 hypothetical protein -
NEH16_RS11070 (NEH16_11050) 2502577..2502969 - 393 WP_265541730.1 hypothetical protein -
NEH16_RS11075 (NEH16_11055) 2502969..2504684 - 1716 WP_265541732.1 hypothetical protein -
NEH16_RS11080 (NEH16_11060) 2504950..2505219 + 270 WP_265541734.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NEH16_RS11085 (NEH16_11065) 2505212..2505475 + 264 WP_265541736.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NEH16_RS11090 (NEH16_11070) 2505605..2506693 - 1089 WP_265541738.1 redox-regulated ATPase YchF -
NEH16_RS11095 (NEH16_11075) 2506813..2508050 - 1238 Protein_2201 GNAT family N-acetyltransferase -
NEH16_RS11100 (NEH16_11080) 2508120..2509172 - 1053 WP_265541740.1 peptidase C39 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-59)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9967.48 Da        Isoelectric Point: 10.2328

>T247944 WP_265541736.1 NZ_CP098740:2505212-2505475 [Streptomyces drozdowiczii]
VSKYRTVFRPEAQAELRKIPRGMALRILAKLAELESDPLGFNTTALVSQPDRRRLRVGDYRVVYTIDNGEVVVWVVHIGH
RSTVYDT

Download         Length: 264 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10278.67 Da        Isoelectric Point: 4.6265

>AT247944 WP_265541734.1 NZ_CP098740:2504950-2505219 [Streptomyces drozdowiczii]
MTQPQPIESIRAVRAHLAEVVERADRDDVPTVITRRGKQVAAIVSIEVLRKYQEWEEREINRIIDERMADSAPGIPIEDV
MRETLERGE

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References