247943

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1442212..1443128 Replicon chromosome
Accession NZ_CP098738
Organism Bacillus halotolerans strain XE48

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag NDR85_RS07305 Protein ID WP_044156223.1
Coordinates 1442382..1443128 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A7G7U9Y3
Locus tag NDR85_RS07300 Protein ID WP_024121090.1
Coordinates 1442212..1442382 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDR85_RS07265 (NDR85_07255) 1439076..1439405 + 330 WP_044156231.1 XkdW family protein -
NDR85_RS07270 (NDR85_07260) 1439402..1439566 + 165 WP_044156230.1 XkdX family protein -
NDR85_RS07275 (NDR85_07265) 1439610..1440449 + 840 WP_044156229.1 hypothetical protein -
NDR85_RS07280 (NDR85_07270) 1440505..1440774 + 270 WP_044156228.1 hemolysin XhlA family protein -
NDR85_RS07285 (NDR85_07275) 1440786..1441049 + 264 WP_044156226.1 phage holin -
NDR85_RS07290 (NDR85_07280) 1441062..1441955 + 894 WP_044156225.1 N-acetylmuramoyl-L-alanine amidase -
NDR85_RS07295 (NDR85_07285) 1441991..1442128 - 138 WP_125825426.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
NDR85_RS07300 (NDR85_07290) 1442212..1442382 - 171 WP_024121090.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NDR85_RS07305 (NDR85_07295) 1442382..1443128 - 747 WP_044156223.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NDR85_RS07310 (NDR85_07300) 1443237..1444238 - 1002 WP_044156221.1 inorganic phosphate transporter -
NDR85_RS07315 (NDR85_07305) 1444251..1444868 - 618 WP_044156219.1 DUF47 domain-containing protein -
NDR85_RS07320 (NDR85_07310) 1445146..1446462 - 1317 WP_044156218.1 serine/threonine exchanger -
NDR85_RS07325 (NDR85_07315) 1446857..1447807 + 951 WP_044156217.1 ring-cleaving dioxygenase -
NDR85_RS07330 (NDR85_07320) 1447973..1448053 + 81 Protein_1381 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29102.52 Da        Isoelectric Point: 4.4373

>T247943 WP_044156223.1 NZ_CP098738:c1443128-1442382 [Bacillus halotolerans]
MLLFFQIMVWCTMAALGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMIYWTYDPSSLFTNWERYVIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLDRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CYYSTQSDKDRLTEHMEDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6578.62 Da        Isoelectric Point: 10.9236

>AT247943 WP_024121090.1 NZ_CP098738:c1442382-1442212 [Bacillus halotolerans]
MENAFQNGCHPRAKKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7U9Y3

References