Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1829752..1831367 Replicon chromosome
Accession NZ_CP098735
Organism Cupriavidus gilardii strain QJ1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NDR89_RS08135 Protein ID WP_252251685.1
Coordinates 1830018..1831367 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NDR89_RS08130 Protein ID WP_252251684.1
Coordinates 1829752..1830015 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDR89_RS08105 (NDR89_08105) 1825187..1825552 + 366 WP_252251679.1 DUF3613 domain-containing protein -
NDR89_RS08110 (NDR89_08110) 1825558..1827255 + 1698 WP_276534967.1 TadG family pilus assembly protein -
NDR89_RS08115 (NDR89_08115) 1827314..1828684 + 1371 WP_252251681.1 sigma-54 dependent transcriptional regulator -
NDR89_RS08120 (NDR89_08120) 1828753..1829109 - 357 WP_252251682.1 helix-turn-helix transcriptional regulator -
NDR89_RS08125 (NDR89_08125) 1829125..1829520 - 396 WP_252251683.1 hypothetical protein -
NDR89_RS08130 (NDR89_08130) 1829752..1830015 + 264 WP_252251684.1 helix-turn-helix transcriptional regulator Antitoxin
NDR89_RS08135 (NDR89_08135) 1830018..1831367 + 1350 WP_252251685.1 type II toxin-antitoxin system HipA family toxin Toxin
NDR89_RS08140 (NDR89_08140) 1831426..1833540 - 2115 WP_252251686.1 TonB-dependent siderophore receptor -
NDR89_RS08145 (NDR89_08145) 1833765..1834700 - 936 WP_252251687.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-67)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 50088.23 Da        Isoelectric Point: 7.0049

>T247939 WP_252251685.1 NZ_CP098735:1830018-1831367 [Cupriavidus gilardii]
MGRRSHTRTLTLWMNGAFVGTWHFSPRAGDVLQYAPEWVASGAGRPLSLSLPFTPGNAPHRGDKVRAYFDNLLPDTREIR
ERIARRYRTGSTDAFDLLAEIGRDCVGALQLLPDGTVPEGVQPVAAEPLTEAQVAQVLRGTLRSAPPGFVDEQDEFRISI
AGAQEKTALLYDNGAWCLPHGQTPTTHILKLPLGLVGGLKLNMTESVENEWLCSLILRQFGLPVAHCEPVQFEDLKALSV
QRFDRMWWQSPDGDRRLVRLPQEDMCQAKGVPPAFKYEADGGPGIDSIMETLAGSTTRDEDRRTFFQAQVLFWMLRATDG
HAKNFSLFLRPEGRYQLTPLYDVLSAYPIIGEAPGKLSPFRVKMAMAVRTRNAHYQMREIQRRHWLAVGERHGVITADGR
PARYVLDDLAERAPRVAQAIREALPKSFPEPLADCILDGMLAEAERLAG

Download         Length: 1350 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9488.96 Da        Isoelectric Point: 10.9887

>AT247939 WP_252251684.1 NZ_CP098735:1829752-1830015 [Cupriavidus gilardii]
MSNFTVRTAEQLPQLLQAFRKEAGLTQAEAALRMGVSQQTLSALERNPARVSVDKLMRVLSVLGVELVLHKPAPQPHNGA
SSSPQVW

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References