Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
Location | 1829752..1831367 | Replicon | chromosome |
Accession | NZ_CP098735 | ||
Organism | Cupriavidus gilardii strain QJ1 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | NDR89_RS08135 | Protein ID | WP_252251685.1 |
Coordinates | 1830018..1831367 (+) | Length | 450 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | NDR89_RS08130 | Protein ID | WP_252251684.1 |
Coordinates | 1829752..1830015 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NDR89_RS08105 (NDR89_08105) | 1825187..1825552 | + | 366 | WP_252251679.1 | DUF3613 domain-containing protein | - |
NDR89_RS08110 (NDR89_08110) | 1825558..1827255 | + | 1698 | WP_276534967.1 | TadG family pilus assembly protein | - |
NDR89_RS08115 (NDR89_08115) | 1827314..1828684 | + | 1371 | WP_252251681.1 | sigma-54 dependent transcriptional regulator | - |
NDR89_RS08120 (NDR89_08120) | 1828753..1829109 | - | 357 | WP_252251682.1 | helix-turn-helix transcriptional regulator | - |
NDR89_RS08125 (NDR89_08125) | 1829125..1829520 | - | 396 | WP_252251683.1 | hypothetical protein | - |
NDR89_RS08130 (NDR89_08130) | 1829752..1830015 | + | 264 | WP_252251684.1 | helix-turn-helix transcriptional regulator | Antitoxin |
NDR89_RS08135 (NDR89_08135) | 1830018..1831367 | + | 1350 | WP_252251685.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
NDR89_RS08140 (NDR89_08140) | 1831426..1833540 | - | 2115 | WP_252251686.1 | TonB-dependent siderophore receptor | - |
NDR89_RS08145 (NDR89_08145) | 1833765..1834700 | - | 936 | WP_252251687.1 | LysR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 450 a.a. Molecular weight: 50088.23 Da Isoelectric Point: 7.0049
>T247939 WP_252251685.1 NZ_CP098735:1830018-1831367 [Cupriavidus gilardii]
MGRRSHTRTLTLWMNGAFVGTWHFSPRAGDVLQYAPEWVASGAGRPLSLSLPFTPGNAPHRGDKVRAYFDNLLPDTREIR
ERIARRYRTGSTDAFDLLAEIGRDCVGALQLLPDGTVPEGVQPVAAEPLTEAQVAQVLRGTLRSAPPGFVDEQDEFRISI
AGAQEKTALLYDNGAWCLPHGQTPTTHILKLPLGLVGGLKLNMTESVENEWLCSLILRQFGLPVAHCEPVQFEDLKALSV
QRFDRMWWQSPDGDRRLVRLPQEDMCQAKGVPPAFKYEADGGPGIDSIMETLAGSTTRDEDRRTFFQAQVLFWMLRATDG
HAKNFSLFLRPEGRYQLTPLYDVLSAYPIIGEAPGKLSPFRVKMAMAVRTRNAHYQMREIQRRHWLAVGERHGVITADGR
PARYVLDDLAERAPRVAQAIREALPKSFPEPLADCILDGMLAEAERLAG
MGRRSHTRTLTLWMNGAFVGTWHFSPRAGDVLQYAPEWVASGAGRPLSLSLPFTPGNAPHRGDKVRAYFDNLLPDTREIR
ERIARRYRTGSTDAFDLLAEIGRDCVGALQLLPDGTVPEGVQPVAAEPLTEAQVAQVLRGTLRSAPPGFVDEQDEFRISI
AGAQEKTALLYDNGAWCLPHGQTPTTHILKLPLGLVGGLKLNMTESVENEWLCSLILRQFGLPVAHCEPVQFEDLKALSV
QRFDRMWWQSPDGDRRLVRLPQEDMCQAKGVPPAFKYEADGGPGIDSIMETLAGSTTRDEDRRTFFQAQVLFWMLRATDG
HAKNFSLFLRPEGRYQLTPLYDVLSAYPIIGEAPGKLSPFRVKMAMAVRTRNAHYQMREIQRRHWLAVGERHGVITADGR
PARYVLDDLAERAPRVAQAIREALPKSFPEPLADCILDGMLAEAERLAG
Download Length: 1350 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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