Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1752470..1754112 Replicon chromosome
Accession NZ_CP098732
Organism Acinetobacter tibetensis strain Y-23

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M5E07_RS08475 Protein ID WP_252218470.1
Coordinates 1752470..1753801 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M5E07_RS08480 Protein ID WP_252218471.1
Coordinates 1753798..1754112 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5E07_RS08460 (M5E07_08460) 1748971..1750371 + 1401 WP_252218467.1 dihydrolipoyl dehydrogenase -
M5E07_RS08465 (M5E07_08465) 1750383..1751168 + 786 WP_252218469.1 acetoin reductase -
M5E07_RS08470 (M5E07_08470) 1751193..1752251 + 1059 WP_116763636.1 2,3-butanediol dehydrogenase -
M5E07_RS08475 (M5E07_08475) 1752470..1753801 + 1332 WP_252218470.1 HipA domain-containing protein Toxin
M5E07_RS08480 (M5E07_08480) 1753798..1754112 + 315 WP_252218471.1 helix-turn-helix domain-containing protein Antitoxin
M5E07_RS08485 (M5E07_08485) 1754342..1754923 + 582 WP_252218472.1 TetR/AcrR family transcriptional regulator -
M5E07_RS08490 (M5E07_08490) 1755107..1755241 + 135 WP_252218473.1 NAD(P)-binding domain-containing protein -
M5E07_RS08495 (M5E07_08495) 1755284..1756489 + 1206 WP_252218475.1 MFS transporter -
M5E07_RS08500 (M5E07_08500) 1756859..1757410 + 552 WP_252218478.1 shikimate kinase -
M5E07_RS08505 (M5E07_08505) 1757440..1757734 - 295 Protein_1644 hypothetical protein -
M5E07_RS08510 (M5E07_08510) 1757987..1758541 + 555 WP_252218481.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-357)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50878.82 Da        Isoelectric Point: 4.9160

>T247936 WP_252218470.1 NZ_CP098732:1752470-1753801 [Acinetobacter tibetensis]
MKKLTIQALLDKNWLDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESSTWFGFLDDIVP
SGAARRYWVNYLDLQRLSYAEQESILLEKGGIAPVGNLRIKEALPALNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQESFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWLNDQWHRHGLESVYSVLNKSSGSHLNHFEVIENLCKLLTRIDSDFDAAQFICEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKISLSPIYDFAPMKADPEVVIRSTTWGSPYEEGGEYRWADITQKLAPWCDPDVSLGTLK
TLARNLVGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11857.78 Da        Isoelectric Point: 9.7356

>AT247936 WP_252218471.1 NZ_CP098732:1753798-1754112 [Acinetobacter tibetensis]
MNMKNQTQDRQQVLIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYAALVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVNKIIKPSDEH

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References