Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2721060..2721589 Replicon chromosome
Accession NZ_CP098727
Organism Staphylococcus aureus strain SauR3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LC189_RS13270 Protein ID WP_000621175.1
Coordinates 2721227..2721589 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LC189_RS13265 Protein ID WP_000948331.1
Coordinates 2721060..2721230 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LC189_RS13235 (LC189_013235) 2716096..2716656 + 561 WP_001092409.1 K(+)-transporting ATPase subunit C -
LC189_RS13240 (LC189_013240) 2716865..2717344 + 480 WP_001287079.1 hypothetical protein -
LC189_RS13245 (LC189_013245) 2717337..2718920 + 1584 WP_001294620.1 PH domain-containing protein -
LC189_RS13250 (LC189_013250) 2718907..2719398 + 492 WP_001205912.1 PH domain-containing protein -
LC189_RS13255 (LC189_013255) 2719402..2719761 + 360 WP_000581197.1 holo-ACP synthase -
LC189_RS13260 (LC189_013260) 2719827..2720975 + 1149 WP_001281154.1 alanine racemase -
LC189_RS13265 (LC189_013265) 2721060..2721230 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LC189_RS13270 (LC189_013270) 2721227..2721589 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LC189_RS13275 (LC189_013275) 2721939..2722940 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
LC189_RS13280 (LC189_013280) 2723059..2723385 + 327 WP_001052491.1 anti-sigma factor antagonist -
LC189_RS13285 (LC189_013285) 2723387..2723866 + 480 WP_001190829.1 anti-sigma B factor RsbW -
LC189_RS13290 (LC189_013290) 2723841..2724611 + 771 WP_001041102.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T247933 WP_000621175.1 NZ_CP098727:2721227-2721589 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT247933 WP_000948331.1 NZ_CP098727:2721060-2721230 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References