Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2701317..2701831 Replicon chromosome
Accession NZ_CP098727
Organism Staphylococcus aureus strain SauR3

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LC189_RS13180 Protein ID WP_000581792.1
Coordinates 2701622..2701831 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LC189_RS13175 Protein ID WP_000138932.1
Coordinates 2701317..2701610 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LC189_RS13155 (LC189_013155) 2696921..2697562 + 642 WP_000483164.1 thiamine phosphate synthase -
LC189_RS13160 (LC189_013160) 2697648..2698520 + 873 WP_000725802.1 membrane protein insertase YidC -
LC189_RS13165 (LC189_013165) 2698992..2699639 - 648 WP_001187629.1 HD domain-containing protein -
LC189_RS13170 (LC189_013170) 2699667..2701151 - 1485 WP_000571549.1 cardiolipin synthase -
LC189_RS13175 (LC189_013175) 2701317..2701610 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LC189_RS13180 (LC189_013180) 2701622..2701831 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LC189_RS13185 (LC189_013185) 2701959..2702096 + 138 WP_000828354.1 Lmo0850 family protein -
LC189_RS13190 (LC189_013190) 2702360..2703562 - 1203 WP_224826872.1 FtsW/RodA/SpoVE family cell cycle protein -
LC189_RS13195 (LC189_013195) 2703880..2704950 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
LC189_RS13200 (LC189_013200) 2704965..2706323 + 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T247932 WP_000581792.1 NZ_CP098727:2701622-2701831 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT247932 WP_000138932.1 NZ_CP098727:2701317-2701610 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References