24793

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 349526..350175 Replicon chromosome
Accession NC_014228
Organism Xenorhabdus nematophila ATCC 19061

Toxin (Protein)


Gene name vagD Uniprot ID D3VI06
Locus tag XNC1_RS01795 Protein ID WP_013183266.1
Coordinates 349750..350175 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID N1NH79
Locus tag XNC1_RS01790 Protein ID WP_010845293.1
Coordinates 349526..349753 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC1_RS01775 (XNC1_0412) 345287..346003 + 717 WP_013183262.1 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB -
XNC1_RS01780 (XNC1_0413) 346050..348224 + 2175 WP_065814196.1 DNA helicase II -
XNC1_RS01785 (XNC1_0415) 348313..349263 + 951 WP_010845294.1 magnesium/cobalt transporter CorA -
XNC1_RS01790 (XNC1_0417) 349526..349753 + 228 WP_010845293.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
XNC1_RS01795 (XNC1_0418) 349750..350175 + 426 WP_013183266.1 type II toxin-antitoxin system VapC family toxin Toxin
XNC1_RS01800 (XNC1_0419) 350310..351200 - 891 WP_010845291.1 EamA family transporter RarD -
XNC1_RS22610 351488..351646 - 159 WP_113935524.1 hypothetical protein -
XNC1_RS01805 (XNC1_0420) 351695..352180 - 486 WP_013183267.1 thioesterase family protein -
XNC1_RS22070 352363..353100 + 738 Protein_345 phospholipase A -
XNC1_RS01815 (XNC1_0424) 353229..355055 + 1827 WP_013183268.1 ATP-dependent DNA helicase RecQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15366.95 Da        Isoelectric Point: 9.2397

>T24793 WP_013183266.1 NC_014228:349750-350175 [Xenorhabdus nematophila ATCC 19061]
MKTVYMLDTNICSFIMREQPVAVIKQLQRCVMNNHLIVVSAITYAEMRFGAVGKKASPKHIVLVDEFCRRLDKILPWDKS
AVDATTKTKIALAAAGTPIGHNDAAIAGHALSVGATLITNNSREFSRVTGLSLEDWANGLI

Download         Length: 426 bp

>T24793 NC_014228:349750-350175 [Xenorhabdus nematophila ATCC 19061]
ATGAAAACAGTTTACATGCTGGATACCAATATTTGTTCATTCATTATGCGTGAACAACCTGTTGCAGTAATTAAACAATT
ACAGAGATGCGTGATGAATAACCATCTGATCGTTGTATCTGCGATTACTTATGCGGAAATGCGCTTCGGGGCAGTTGGAA
AGAAAGCTTCCCCGAAACATATTGTATTAGTTGATGAGTTTTGTAGACGATTAGATAAAATTTTACCTTGGGATAAATCC
GCGGTAGACGCAACAACTAAAACAAAGATTGCATTAGCTGCTGCTGGAACGCCTATTGGACATAATGATGCTGCTATTGC
AGGGCATGCTTTGTCTGTAGGAGCGACATTGATAACAAACAATAGTCGTGAATTTTCTCGTGTCACTGGACTATCATTAG
AAGATTGGGCTAACGGGCTGATTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.82 Da        Isoelectric Point: 4.3775

>AT24793 WP_010845293.1 NC_014228:349526-349753 [Xenorhabdus nematophila ATCC 19061]
MRTVAIFKNGNNRAIRLPKDLDFEGVNELEIIREGEAIILRPIKPSWDSFLYEDKADADFLSERPDIVEEGRVNL

Download         Length: 228 bp

>AT24793 NC_014228:349526-349753 [Xenorhabdus nematophila ATCC 19061]
ATGCGAACTGTAGCAATTTTTAAAAATGGTAATAATCGCGCTATCCGTTTACCTAAAGATCTGGATTTTGAAGGCGTAAA
TGAACTGGAGATTATCCGTGAAGGAGAAGCCATTATATTGCGTCCGATAAAACCCAGTTGGGATTCATTTCTTTATGAGG
ACAAAGCAGACGCAGATTTTCTGTCTGAACGCCCAGATATTGTCGAGGAAGGGCGTGTGAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3VI06

Antitoxin

Source ID Structure
AlphaFold DB N1NH79

References