Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 120313..121089 Replicon chromosome
Accession NZ_CP098727
Organism Staphylococcus aureus strain SauR3

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LC189_RS00760 Protein ID WP_000031108.1
Coordinates 120937..121089 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag LC189_RS00755 Protein ID WP_001251228.1
Coordinates 120313..120912 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LC189_RS00735 (LC189_000735) 116230..117687 + 1458 WP_224558358.1 ABC transporter permease subunit -
LC189_RS00740 (LC189_000740) 117680..118402 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
LC189_RS00745 (LC189_000745) 118553..119680 + 1128 WP_000379985.1 tRNA epoxyqueuosine(34) reductase QueG -
LC189_RS00750 (LC189_000750) 119685..120155 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LC189_RS00755 (LC189_000755) 120313..120912 + 600 WP_001251228.1 glucosamine-6-phosphate isomerase Antitoxin
LC189_RS00760 (LC189_000760) 120937..121089 + 153 WP_000031108.1 SAS053 family protein Toxin
LC189_RS00765 (LC189_000765) 121981..122376 + 396 WP_000901023.1 hypothetical protein -
LC189_RS00770 (LC189_000770) 122572..123957 + 1386 WP_000116229.1 class II fumarate hydratase -
LC189_RS00775 (LC189_000775) 124416..125237 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T247923 WP_000031108.1 NZ_CP098727:120937-121089 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT247923 WP_001251228.1 NZ_CP098727:120313-120912 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEGLGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNIILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References