Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1877390..1878308 Replicon chromosome
Accession NZ_CP098724
Organism Yersinia ruckeri strain NVI-10571

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag ND438_RS08385 Protein ID WP_038242633.1
Coordinates 1877850..1878308 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A085U7R3
Locus tag ND438_RS08380 Protein ID WP_038242631.1
Coordinates 1877390..1877836 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND438_RS08360 (ND438_08355) 1873088..1873792 + 705 WP_004717543.1 murein tripeptide amidase MpaA -
ND438_RS08365 (ND438_08360) 1873803..1874777 - 975 WP_071706618.1 L-Ala-D/L-Glu epimerase -
ND438_RS08370 (ND438_08365) 1874927..1875430 + 504 WP_004717547.1 thiol peroxidase -
ND438_RS08375 (ND438_08370) 1875465..1877072 - 1608 WP_096823414.1 transcriptional regulator TyrR -
ND438_RS08380 (ND438_08375) 1877390..1877836 + 447 WP_038242631.1 DUF2384 domain-containing protein Antitoxin
ND438_RS08385 (ND438_08380) 1877850..1878308 + 459 WP_038242633.1 RES domain-containing protein Toxin
ND438_RS08390 (ND438_08385) 1878312..1879370 - 1059 WP_038242635.1 YcjF family protein -
ND438_RS08395 (ND438_08390) 1879367..1880764 - 1398 WP_004717556.1 YcjX family protein -
ND438_RS08400 (ND438_08395) 1880745..1880987 - 243 WP_096823415.1 phage shock protein PspD -
ND438_RS08405 (ND438_08400) 1881051..1881410 - 360 WP_004717559.1 envelope stress response membrane protein PspC -
ND438_RS08410 (ND438_08405) 1881410..1881637 - 228 WP_038242637.1 envelope stress response membrane protein PspB -
ND438_RS08415 (ND438_08410) 1881721..1882386 - 666 WP_038275968.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17072.55 Da        Isoelectric Point: 6.6384

>T247915 WP_038242633.1 NZ_CP098724:1877850-1878308 [Yersinia ruckeri]
VMLYRIVHNRYLATAWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHVEDSATLNDFNLFQITIPDNAIMVLQQQ
DWPRGWRDDPTPVATMDIGTEWIGSVSSVGLLVPSTLVPLERNMLVNPKHRDFASCLKSINPLTFSFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16406.87 Da        Isoelectric Point: 8.0956

>AT247915 WP_038242631.1 NZ_CP098724:1877390-1877836 [Yersinia ruckeri]
MRTYHPSPMAKVSALWREIGLPASRGTALVDSIKLGFTVDVIDTIHLWADMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDRTKATAWMSMPVKGLGNRTPDSLLETETGALEICDLIGRLEHGVFS

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A085U7R3

References