Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 457644..459364 Replicon chromosome
Accession NZ_CP098724
Organism Yersinia ruckeri strain NVI-10571

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag ND438_RS02095 Protein ID WP_096823271.1
Coordinates 457644..458300 (+) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag ND438_RS02100 Protein ID WP_096823272.1
Coordinates 458297..459364 (+) Length 356 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND438_RS02065 (ND438_02065) 452863..453807 - 945 WP_038275265.1 hypothetical protein -
ND438_RS02070 (ND438_02070) 454322..455581 + 1260 Protein_399 integrase arm-type DNA-binding domain-containing protein -
ND438_RS02075 (ND438_02075) 455755..456009 + 255 WP_005175264.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ND438_RS02080 (ND438_02080) 455999..456289 + 291 WP_071666901.1 type II toxin-antitoxin system RelE/ParE family toxin -
ND438_RS02085 (ND438_02085) 456553..456942 + 390 WP_096823270.1 restriction endonuclease subunit S -
ND438_RS02090 (ND438_02090) 457066..457641 + 576 WP_071706520.1 DarT ssDNA thymidine ADP-ribosyltransferase family protein -
ND438_RS02095 (ND438_02095) 457644..458300 + 657 WP_096823271.1 DUF4433 domain-containing protein Toxin
ND438_RS02100 (ND438_02100) 458297..459364 + 1068 WP_096823272.1 macro domain-containing protein Antitoxin
ND438_RS02105 (ND438_02105) 459385..459651 + 267 Protein_406 hypothetical protein -
ND438_RS02110 (ND438_02110) 459726..459860 + 135 Protein_407 transposase -
ND438_RS02115 (ND438_02115) 459863..460360 + 498 Protein_408 IS30-like element ISYkr1 family transposase -
ND438_RS02120 (ND438_02120) 460366..461059 + 694 Protein_409 IS3 family transposase -
ND438_RS02125 (ND438_02125) 461369..462280 - 912 WP_096823274.1 EamA family transporter -
ND438_RS02130 (ND438_02130) 462437..463114 + 678 WP_096823275.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 446192..464449 18257


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-217)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25214.72 Da        Isoelectric Point: 6.6007

>T247913 WP_096823271.1 NZ_CP098724:457644-458300 [Yersinia ruckeri]
VAYDYSTSLNPEKALIWRIVHRDNIPWILDNGLHCGNSPVQAEDWINIGNPELIDKRAGHLVPTGMRGTLHDYVPFYFTP
FSPMLMNIRSGRGGIKQRPNEEIVILVSSLRNMVAQNVSFVFTDSHAYYNLANYFTELDSLNQIDWPILQARDFRRDQDD
LAKFERYQAEALIWKHCPIALLGGMICYNDGVRLQLEQWLSQRNLSMPVHARAGWYFS

Download         Length: 657 bp

Antitoxin


Download         Length: 356 a.a.        Molecular weight: 40847.21 Da        Isoelectric Point: 6.3136

>AT247913 WP_096823272.1 NZ_CP098724:458297-459364 [Yersinia ruckeri]
MITFTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPVNMKAYALACKHKQVMTGKMFITETGELMGPRWIVNFPTK
QHWRADSRMEWVEDGLQDLRRFLIEEKVQSIAIPPLGAGNGGLNWSDVRMRIESALGDLQDTEILIYEPTEKYQNVAKST
GVKKLTPARALIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQEDVLKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDTQPLDVIWFNDQEKEHINLWLNNEAKEWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGKCQPTLDSVKEG
LHQWPAGERWASRKMKLFDDKNLQFAINRVMEFHC

Download         Length: 1068 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References