247911

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3142104..3142638 Replicon chromosome
Accession NZ_CP098723
Organism Yersinia ruckeri strain NVI-11065

Toxin (Protein)


Gene name relE Uniprot ID A0A0T9LYG3
Locus tag ND444_RS14230 Protein ID WP_038275268.1
Coordinates 3142104..3142394 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A1JJ37
Locus tag ND444_RS14235 Protein ID WP_005175264.1
Coordinates 3142384..3142638 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND444_RS14180 (ND444_14165) 3137380..3137610 - 231 Protein_2747 DUF4942 domain-containing protein -
ND444_RS14185 (ND444_14170) 3137760..3137888 + 129 Protein_2748 helix-turn-helix domain-containing protein -
ND444_RS14190 (ND444_14175) 3137881..3138001 + 121 Protein_2749 transposase -
ND444_RS14195 (ND444_14180) 3138030..3138326 - 297 Protein_2750 integrase core domain-containing protein -
ND444_RS14200 (ND444_14185) 3138325..3138723 + 399 Protein_2751 integrase core domain-containing protein -
ND444_RS14205 (ND444_14190) 3138742..3139008 - 267 Protein_2752 hypothetical protein -
ND444_RS14210 (ND444_14195) 3139029..3140096 - 1068 WP_096823272.1 macro domain-containing protein -
ND444_RS14215 (ND444_14200) 3140093..3140749 - 657 WP_096823271.1 DUF4433 domain-containing protein -
ND444_RS14220 (ND444_14205) 3140752..3141327 - 576 WP_265315943.1 DUF4433 domain-containing protein -
ND444_RS14225 (ND444_14210) 3141451..3141840 - 390 WP_265315942.1 restriction endonuclease subunit S -
ND444_RS14230 (ND444_14215) 3142104..3142394 - 291 WP_038275268.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ND444_RS14235 (ND444_14220) 3142384..3142638 - 255 WP_005175264.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ND444_RS14240 (ND444_14225) 3142812..3143207 - 396 Protein_2759 tyrosine-type recombinase/integrase -
ND444_RS14245 (ND444_14230) 3143232..3144382 - 1151 Protein_2760 IS3 family transposase -
ND444_RS14250 (ND444_14235) 3144672..3146234 + 1563 WP_265315941.1 AAA family ATPase -
ND444_RS14255 (ND444_14240) 3146219..3147241 + 1023 WP_265315940.1 TGBp1 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3138030..3173436 35406
- flank IS/Tn - - 3138030..3138278 248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11494.42 Da        Isoelectric Point: 9.9816

>T247911 WP_038275268.1 NZ_CP098723:c3142394-3142104 [Yersinia ruckeri]
MTFNIDFDERALKEWHKLDKTIREQFKKKLRKLQENPYIESARLHGDLAGCFKIKLRASGFRLIYQVIDEEIVIWIVAVG
KREDEKAYDIAKKRIQ

Download         Length: 291 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9680.07 Da        Isoelectric Point: 4.8283

>AT247911 WP_005175264.1 NZ_CP098723:c3142638-3142384 [Yersinia ruckeri]
MSTIQIRVDDELKKSAYQAFEKLNLSPSDALRLFLRYVAENEKLPFSEVSVMVSNQDEDADILAVVRERLKNPAKRIRVN
IDDL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9LYG3

Antitoxin

Source ID Structure
AlphaFold DB A1JJ37

References