247909

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 3135967..3137305 Replicon chromosome
Accession NZ_CP098723
Organism Yersinia ruckeri strain NVI-11065

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag ND444_RS14170 Protein ID WP_234049238.1
Coordinates 3135967..3136917 (-) Length 317 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A848MNT5
Locus tag ND444_RS14175 Protein ID WP_038245317.1
Coordinates 3136910..3137305 (-) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND444_RS14150 (ND444_14135) 3132778..3133470 - 693 WP_038245321.1 oligogalacturonate-specific porin KdgM family protein -
ND444_RS14155 (ND444_14140) 3133518..3134672 - 1155 WP_038245380.1 N-acetylneuraminate epimerase -
ND444_RS14160 (ND444_14145) 3135275..3135448 - 174 Protein_2743 type IV toxin-antitoxin system YeeU family antitoxin -
ND444_RS14165 (ND444_14150) 3135474..3135599 - 126 Protein_2744 antirestriction protein -
ND444_RS14170 (ND444_14155) 3135967..3136917 - 951 WP_234049238.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
ND444_RS14175 (ND444_14160) 3136910..3137305 - 396 WP_038245317.1 DUF6088 family protein Antitoxin
ND444_RS14180 (ND444_14165) 3137380..3137610 - 231 Protein_2747 DUF4942 domain-containing protein -
ND444_RS14185 (ND444_14170) 3137760..3137888 + 129 Protein_2748 helix-turn-helix domain-containing protein -
ND444_RS14190 (ND444_14175) 3137881..3138001 + 121 Protein_2749 transposase -
ND444_RS14195 (ND444_14180) 3138030..3138326 - 297 Protein_2750 integrase core domain-containing protein -
ND444_RS14200 (ND444_14185) 3138325..3138723 + 399 Protein_2751 integrase core domain-containing protein -
ND444_RS14205 (ND444_14190) 3138742..3139008 - 267 Protein_2752 hypothetical protein -
ND444_RS14210 (ND444_14195) 3139029..3140096 - 1068 WP_096823272.1 macro domain-containing protein -
ND444_RS14215 (ND444_14200) 3140093..3140749 - 657 WP_096823271.1 DUF4433 domain-containing protein -
ND444_RS14220 (ND444_14205) 3140752..3141327 - 576 WP_265315943.1 DUF4433 domain-containing protein -
ND444_RS14225 (ND444_14210) 3141451..3141840 - 390 WP_265315942.1 restriction endonuclease subunit S -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3138030..3138278 248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 317 a.a.        Molecular weight: 36070.39 Da        Isoelectric Point: 4.5996

>T247909 WP_234049238.1 NZ_CP098723:c3136917-3135967 [Yersinia ruckeri]
MDDLTKLFPDVADALGIESVSIVEKDYYIVELLRLLQPLDFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPVAGFTQ
QYSRGQRKDIRKGIIRTVIETITASGTFRMDEGYPKVTRDEYRYNEIPVRYPQEYVQVPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGADVPVLKQFV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELVSNPVYKERYLQFVTPMVFGESHVSWEEAYACFRKTVLDVVDA

Download         Length: 951 bp


Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14406.76 Da        Isoelectric Point: 11.0360

>AT247909 WP_038245317.1 NZ_CP098723:c3137305-3136910 [Yersinia ruckeri]
MTTKARIQLRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLKVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG

Download         Length: 396 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A848MNT5

References