Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2691806..2692429 Replicon chromosome
Accession NZ_CP098723
Organism Yersinia ruckeri strain NVI-11065

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag ND444_RS12275 Protein ID WP_038243726.1
Coordinates 2692226..2692429 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag ND444_RS12270 Protein ID WP_004718732.1
Coordinates 2691806..2692174 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND444_RS12255 (ND444_12245) 2690059..2690313 + 255 WP_267260601.1 type B 50S ribosomal protein L31 -
ND444_RS12260 (ND444_12250) 2690333..2690476 + 144 WP_004718738.1 type B 50S ribosomal protein L36 -
ND444_RS12265 (ND444_12255) 2690595..2690732 - 138 WP_186368427.1 hypothetical protein -
ND444_RS12270 (ND444_12260) 2691806..2692174 + 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
ND444_RS12275 (ND444_12265) 2692226..2692429 + 204 WP_038243726.1 expression modulating protein YmoA Toxin
ND444_RS12285 (ND444_12275) 2693238..2693552 + 315 WP_004718728.1 MGMT family protein -
ND444_RS12290 (ND444_12280) 2693930..2694793 + 864 WP_004718726.1 acyl-CoA thioesterase II -
ND444_RS12295 (ND444_12285) 2694908..2696197 - 1290 WP_265316202.1 ammonium transporter AmtB -
ND444_RS12300 (ND444_12290) 2696236..2696574 - 339 WP_007886947.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T247908 WP_038243726.1 NZ_CP098723:2692226-2692429 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT247908 WP_004718732.1 NZ_CP098723:2691806-2692174 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References