Detailed information of TA system TA024789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3061632..3062282
• Replicon: chromosome
• Accession: NC_014221
• Organism: Truepera radiovictrix DSM 17093

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D7CVK9
• Locus tag: TRAD_RS14055
• Protein ID: WP_013179279.1
• Coordinates: 3061632..3062036 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: TRAD_RS14060
• Protein ID: WP_041947326.1
• Coordinates: 3062049..3062282 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TRAD_RS14035	3056991..3058016	-	1026	WP_041948141.1	anthranilate phosphoribosyltransferase	-
TRAD_RS14040	3058043..3058885	-	843	WP_049773215.1	glycosyltransferase	-
TRAD_RS14045	3058943..3059518	-	576	WP_013179276.1	aminodeoxychorismate/anthranilate synthase component II	-
TRAD_RS15815	3059627..3060001	-	375	WP_148221264.1	four helix bundle protein	-
TRAD_RS14050	3060025..3061479	-	1455	WP_013179278.1	anthranilate synthase component I	-
TRAD_RS14055	3061632..3062036	-	405	WP_013179279.1	type II toxin-antitoxin system VapC family toxin	Toxin
TRAD_RS14060	3062049..3062282	-	234	WP_041947326.1	hypothetical protein	Antitoxin
TRAD_RS14065	3062412..3062978	+	567	WP_013179281.1	hypothetical protein	-
TRAD_RS14070	3063032..3063679	-	648	WP_013179282.1	VOC family protein	-
TRAD_RS14075	3063701..3064501	-	801	WP_013179283.1	enoyl-ACP reductase	-
TRAD_RS14080	3064525..3065253	-	729	WP_041948143.1	NAD-dependent protein deacylase	-
TRAD_RS14085	3065292..3066782	-	1491	WP_013179285.1	hemolysin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (3-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15285.66 Da
• Isoelectric Point: 8.0918

>T24789 WP_013179279.1 NC_014221:c3062036-3061632 [Truepera radiovictrix DSM 17093]
VIVLDASAGVSFLLRIEPAYAPLRERVLRAGTLHVPQLFDLEVLHALRRYERQRFISPARAERAFARLRELRCERHPHVP
LAERVWELRANLSAYDATYVALAEILEAPLITLDARLGRAPGHRAQLEVYGEDV

Nucleotide

• Length: 405 bp

>T24789 NC_014221:c3062036-3061632 [Truepera radiovictrix DSM 17093]
GTGATCGTTCTCGACGCCTCCGCCGGGGTGAGCTTTTTGCTCCGGATCGAACCCGCCTACGCGCCGTTGCGCGAGCGCGT
CTTGCGCGCAGGGACGCTTCACGTGCCGCAGCTTTTCGATCTCGAGGTCTTACACGCGCTGAGGCGTTACGAGCGGCAGC
GCTTTATCTCCCCCGCGCGCGCCGAACGCGCCTTTGCGCGGCTGCGCGAGCTGAGGTGCGAGCGCCACCCCCACGTGCCG
CTCGCCGAGCGCGTGTGGGAGCTGCGGGCGAATCTCAGCGCCTACGACGCGACCTACGTGGCGCTCGCCGAGATCCTTGA
AGCTCCCCTCATCACCCTCGACGCCCGCTTGGGCCGCGCGCCGGGGCACCGCGCGCAGCTCGAGGTTTACGGCGAGGACG
TTTAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8704.15 Da
• Isoelectric Point: 5.8527

>AT24789 WP_041947326.1 NC_014221:c3062282-3062049 [Truepera radiovictrix DSM 17093]
MSKMIQIRNVPEALHRKLKMRAAERGMTLSDFLLEQATIAAETPSLEELVRRIDAEPPLALPPEEAPASVIRRLRDD

Nucleotide

• Length: 234 bp

>AT24789 NC_014221:c3062282-3062049 [Truepera radiovictrix DSM 17093]
ATGTCCAAGATGATCCAGATCCGCAACGTCCCCGAAGCGCTGCACCGCAAACTCAAGATGCGGGCGGCGGAGCGGGGGAT
GACCTTGTCGGACTTTTTGCTCGAGCAGGCCACCATCGCGGCGGAGACGCCGAGTTTAGAGGAGCTCGTGCGGCGCATCG
ACGCGGAGCCGCCGCTCGCCCTACCCCCCGAGGAGGCGCCTGCTAGCGTGATCCGCCGACTTCGCGACGACTAG

Structures

Toxin

• AlphaFold DB: D7CVK9