Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2073375..2074293 Replicon chromosome
Accession NZ_CP098719
Organism Yersinia ruckeri strain NVI-11267

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag ND445_RS09425 Protein ID WP_038242633.1
Coordinates 2073835..2074293 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A085U7R3
Locus tag ND445_RS09420 Protein ID WP_038242631.1
Coordinates 2073375..2073821 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND445_RS09400 (ND445_09395) 2069073..2069777 + 705 WP_004717543.1 murein tripeptide amidase MpaA -
ND445_RS09405 (ND445_09400) 2069788..2070762 - 975 WP_071706618.1 L-Ala-D/L-Glu epimerase -
ND445_RS09410 (ND445_09405) 2070912..2071415 + 504 WP_004717547.1 thiol peroxidase -
ND445_RS09415 (ND445_09410) 2071450..2073057 - 1608 WP_096823414.1 transcriptional regulator TyrR -
ND445_RS09420 (ND445_09415) 2073375..2073821 + 447 WP_038242631.1 DUF2384 domain-containing protein Antitoxin
ND445_RS09425 (ND445_09420) 2073835..2074293 + 459 WP_038242633.1 RES domain-containing protein Toxin
ND445_RS09430 (ND445_09425) 2074297..2075355 - 1059 WP_038242635.1 YcjF family protein -
ND445_RS09435 (ND445_09430) 2075352..2076749 - 1398 WP_004717556.1 YcjX family protein -
ND445_RS09440 (ND445_09435) 2076730..2076972 - 243 WP_096823415.1 phage shock protein PspD -
ND445_RS09445 (ND445_09440) 2077036..2077395 - 360 WP_004717559.1 envelope stress response membrane protein PspC -
ND445_RS09450 (ND445_09445) 2077395..2077622 - 228 WP_038242637.1 envelope stress response membrane protein PspB -
ND445_RS09455 (ND445_09450) 2077706..2078371 - 666 WP_038275968.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17072.55 Da        Isoelectric Point: 6.6384

>T247887 WP_038242633.1 NZ_CP098719:2073835-2074293 [Yersinia ruckeri]
VMLYRIVHNRYLATAWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHVEDSATLNDFNLFQITIPDNAIMVLQQQ
DWPRGWRDDPTPVATMDIGTEWIGSVSSVGLLVPSTLVPLERNMLVNPKHRDFASCLKSINPLTFSFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16406.87 Da        Isoelectric Point: 8.0956

>AT247887 WP_038242631.1 NZ_CP098719:2073375-2073821 [Yersinia ruckeri]
MRTYHPSPMAKVSALWREIGLPASRGTALVDSIKLGFTVDVIDTIHLWADMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDRTKATAWMSMPVKGLGNRTPDSLLETETGALEICDLIGRLEHGVFS

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A085U7R3

References