Detailed information of TA system TA024787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-VapB
• Location: 1493490..1494169
• Replicon: chromosome
• Accession: NC_014221
• Organism: Truepera radiovictrix DSM 17093

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D7CX07
• Locus tag: TRAD_RS06915
• Protein ID: WP_013177885.1
• Coordinates: 1493490..1493924 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D7CX08
• Locus tag: TRAD_RS06920
• Protein ID: WP_013177886.1
• Coordinates: 1493921..1494169 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TRAD_RS06890	1488556..1488933	+	378	WP_013177879.1	gamma-glutamylcyclotransferase	-
TRAD_RS06895	1489303..1490454	+	1152	WP_013177880.1	homocitrate synthase	-
TRAD_RS06900	1490451..1491722	+	1272	WP_013177881.1	3-isopropylmalate dehydratase large subunit	-
TRAD_RS06905	1491722..1492219	+	498	WP_013177882.1	3-isopropylmalate dehydratase small subunit	-
TRAD_RS15675	1492278..1492445	+	168	WP_013177883.1	lysine biosynthesis protein LysW	-
TRAD_RS06910	1492527..1493432	+	906	WP_013177884.1	lysine biosynthesis protein LysX	-
TRAD_RS06915	1493490..1493924	-	435	WP_013177885.1	type II toxin-antitoxin system VapC family toxin	Toxin
TRAD_RS06920	1493921..1494169	-	249	WP_013177886.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
TRAD_RS06925	1494226..1495266	+	1041	WP_013177887.1	N-acetyl-gamma-glutamyl-phosphate reductase	-
TRAD_RS06930	1495374..1496816	+	1443	WP_013177888.1	amidohydrolase family protein	-
TRAD_RS06935	1496934..1497224	+	291	WP_013177889.1	ribbon-helix-helix domain-containing protein	-
TRAD_RS06940	1497221..1497628	+	408	WP_013177890.1	PIN domain-containing protein	-
TRAD_RS06945	1497625..1498428	+	804	WP_013177891.1	[LysW]-aminoadipate kinase	-
TRAD_RS06950	1498428..1498892	+	465	WP_013177892.1	NUDIX domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-44)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15759.12 Da
• Isoelectric Point: 5.9664

>T24787 WP_013177885.1 NC_014221:c1493924-1493490 [Truepera radiovictrix DSM 17093]
VILLDINPLVYAFRPDAPQHPAYVGWLEKLVNQDAAFGLADIVCSGFIRVVTHPRVFSPPSPLDDALEYLEDIRAQPNCV
ILAPGERHWRIFLQLCHAVGAKGNVVPDAYLAALAIESGSELATADRGVARFPGLRWRHPLDAG

Nucleotide

• Length: 435 bp

>T24787 NC_014221:c1493924-1493490 [Truepera radiovictrix DSM 17093]
GTGATCCTGCTCGACATCAATCCGCTGGTCTACGCCTTTAGACCGGACGCGCCGCAGCACCCGGCGTACGTGGGGTGGCT
CGAAAAGCTCGTCAACCAAGACGCCGCTTTCGGCCTCGCCGATATCGTATGCAGCGGCTTCATACGGGTCGTGACGCATC
CTCGCGTCTTCTCACCGCCGTCCCCTCTAGACGACGCGCTCGAGTACCTAGAGGACATCAGGGCGCAACCCAACTGCGTC
ATCCTGGCACCGGGCGAGCGTCACTGGCGCATCTTTCTCCAGCTCTGCCATGCAGTAGGCGCCAAAGGGAACGTGGTACC
GGACGCCTACCTCGCCGCGCTCGCCATCGAATCGGGTAGCGAGCTAGCGACCGCCGACCGAGGCGTTGCGCGCTTCCCCG
GCCTCAGGTGGCGCCATCCGCTCGACGCGGGCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9198.54 Da
• Isoelectric Point: 9.9858

>AT24787 WP_013177886.1 NC_014221:c1494169-1493921 [Truepera radiovictrix DSM 17093]
MRTTIRLDDELLREAKRLAAETNQTLTAVIEEALRERLARRKGARDRPPFTPKVYRGPAKGLQPGVDLDDNAALLDLMEG
RG

Nucleotide

• Length: 249 bp

>AT24787 NC_014221:c1494169-1493921 [Truepera radiovictrix DSM 17093]
ATGAGAACCACCATTCGTTTGGACGACGAGCTGCTGCGGGAAGCGAAGCGTTTAGCTGCCGAGACGAACCAGACGCTCAC
CGCCGTGATCGAAGAGGCGTTGCGCGAACGACTCGCGCGGCGTAAGGGCGCGCGCGACCGCCCACCTTTTACACCGAAGG
TCTACCGAGGTCCGGCTAAGGGTTTGCAACCGGGGGTAGACCTCGACGACAATGCGGCGCTGCTCGACCTGATGGAAGGC
CGGGGGTGA

Structures

Toxin

• AlphaFold DB: D7CX07

Antitoxin

• AlphaFold DB: D7CX08