Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1877212..1878130 Replicon chromosome
Accession NZ_CP098714
Organism Yersinia ruckeri strain NVI-1176

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag ND442_RS08390 Protein ID WP_038242633.1
Coordinates 1877672..1878130 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A085U7R3
Locus tag ND442_RS08385 Protein ID WP_038242631.1
Coordinates 1877212..1877658 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND442_RS08365 (ND442_08360) 1872910..1873614 + 705 WP_004717543.1 murein tripeptide amidase MpaA -
ND442_RS08370 (ND442_08365) 1873625..1874599 - 975 WP_071706618.1 L-Ala-D/L-Glu epimerase -
ND442_RS08375 (ND442_08370) 1874749..1875252 + 504 WP_004717547.1 thiol peroxidase -
ND442_RS08380 (ND442_08375) 1875287..1876894 - 1608 WP_096823414.1 transcriptional regulator TyrR -
ND442_RS08385 (ND442_08380) 1877212..1877658 + 447 WP_038242631.1 DUF2384 domain-containing protein Antitoxin
ND442_RS08390 (ND442_08385) 1877672..1878130 + 459 WP_038242633.1 RES domain-containing protein Toxin
ND442_RS08395 (ND442_08390) 1878134..1879192 - 1059 WP_038242635.1 YcjF family protein -
ND442_RS08400 (ND442_08395) 1879189..1880586 - 1398 WP_004717556.1 YcjX family protein -
ND442_RS08405 (ND442_08400) 1880567..1880809 - 243 WP_096823415.1 phage shock protein PspD -
ND442_RS08410 (ND442_08405) 1880873..1881232 - 360 WP_004717559.1 envelope stress response membrane protein PspC -
ND442_RS08415 (ND442_08410) 1881232..1881459 - 228 WP_038242637.1 envelope stress response membrane protein PspB -
ND442_RS08420 (ND442_08415) 1881543..1882208 - 666 WP_038275968.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17072.55 Da        Isoelectric Point: 6.6384

>T247865 WP_038242633.1 NZ_CP098714:1877672-1878130 [Yersinia ruckeri]
VMLYRIVHNRYLATAWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHVEDSATLNDFNLFQITIPDNAIMVLQQQ
DWPRGWRDDPTPVATMDIGTEWIGSVSSVGLLVPSTLVPLERNMLVNPKHRDFASCLKSINPLTFSFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16406.87 Da        Isoelectric Point: 8.0956

>AT247865 WP_038242631.1 NZ_CP098714:1877212-1877658 [Yersinia ruckeri]
MRTYHPSPMAKVSALWREIGLPASRGTALVDSIKLGFTVDVIDTIHLWADMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDRTKATAWMSMPVKGLGNRTPDSLLETETGALEICDLIGRLEHGVFS

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A085U7R3

References