Detailed information of TA system TA024786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1074943..1075528
• Replicon: chromosome
• Accession: NC_014221
• Organism: Truepera radiovictrix DSM 17093

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: D7CV99
• Locus tag: TRAD_RS04985
• Protein ID: WP_013177498.1
• Coordinates: 1075178..1075528 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: D7CV98
• Locus tag: TRAD_RS04980
• Protein ID: WP_013177497.1
• Coordinates: 1074943..1075191 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TRAD_RS04960	1070416..1071384	+	969	WP_013177493.1	ribose ABC transporter permease	-
TRAD_RS04965	1071388..1072872	+	1485	WP_013177494.1	xylulokinase	-
TRAD_RS04970	1072869..1073411	+	543	WP_013177495.1	D-lyxose/D-mannose family sugar isomerase	-
TRAD_RS04975	1073408..1074853	+	1446	WP_013177496.1	xylulokinase	-
TRAD_RS04980	1074943..1075191	+	249	WP_013177497.1	ribbon-helix-helix domain-containing protein	Antitoxin
TRAD_RS04985	1075178..1075528	+	351	WP_013177498.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-113)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12858.89 Da
• Isoelectric Point: 9.8605

>T24786 WP_013177498.1 NC_014221:1075178-1075528 [Truepera radiovictrix DSM 17093]
MRRGDIYFADLDPIRGSEANKTRPVVVVSHDALNRVVEERRRGVVTVVPLSSNVERVYAFQVLLPAEVTGLPKDAKAQAE
QVRALAYERFAPAPKGVLPERYLQALGEALKLHLAL

Nucleotide

• Length: 351 bp

>T24786 NC_014221:1075178-1075528 [Truepera radiovictrix DSM 17093]
ATGAGGCGGGGTGACATCTACTTCGCCGACCTAGACCCGATCCGGGGCAGCGAGGCGAACAAAACGCGGCCCGTGGTGGT
CGTGAGCCACGACGCTCTTAACCGCGTCGTCGAGGAGCGGCGGCGAGGCGTGGTGACGGTGGTGCCGCTAAGCAGCAACG
TCGAGCGCGTCTACGCCTTTCAGGTTCTCTTGCCCGCCGAGGTGACCGGTTTGCCAAAGGACGCCAAGGCGCAAGCCGAG
CAGGTTCGGGCCCTAGCGTATGAGCGCTTCGCACCTGCCCCTAAGGGCGTGTTACCCGAACGCTACCTGCAAGCGCTAGG
CGAAGCGCTGAAGCTGCACCTGGCGCTTTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9121.14 Da
• Isoelectric Point: 4.6263

>AT24786 WP_013177497.1 NC_014221:1074943-1075191 [Truepera radiovictrix DSM 17093]
MKVSISARVDEVLLRYLDSYQRAHALKSRSEVLEQAIKALRERELSGQYAQAMAEWDASGDAELWDQTAGDGLLTKDAHE
AG

Nucleotide

• Length: 249 bp

>AT24786 NC_014221:1074943-1075191 [Truepera radiovictrix DSM 17093]
ATGAAGGTGTCCATCAGTGCACGGGTCGATGAGGTGCTCCTTCGGTACCTCGACAGCTATCAACGAGCGCACGCCCTCAA
AAGCCGCAGCGAGGTGCTCGAGCAAGCCATCAAAGCGCTTCGGGAGCGGGAGCTGAGCGGGCAGTACGCACAAGCGATGG
CCGAGTGGGACGCCTCAGGCGACGCCGAACTGTGGGACCAGACCGCCGGTGACGGCCTACTCACCAAGGACGCCCATGAG
GCGGGGTGA

Structures

Toxin

• AlphaFold DB: D7CV99

Antitoxin

• AlphaFold DB: D7CV98