Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 1852289..1852896 Replicon chromosome
Accession NC_014220
Organism Syntrophothermus lipocalidus DSM 12680

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag SLIP_RS08880 Protein ID WP_041433572.1
Coordinates 1852289..1852639 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SLIP_RS08885 Protein ID WP_148216649.1
Coordinates 1852645..1852896 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SLIP_RS08850 1847888..1848736 - 849 WP_041432950.1 HDOD domain-containing protein -
SLIP_RS08855 1848747..1849196 - 450 WP_041433571.1 hypothetical protein -
SLIP_RS08860 1849289..1850011 - 723 WP_041432953.1 rRNA pseudouridine synthase -
SLIP_RS08865 1850038..1850229 - 192 WP_013175936.1 hypothetical protein -
SLIP_RS08870 1850222..1851373 - 1152 WP_013175937.1 amidohydrolase -
SLIP_RS08875 1851491..1852189 - 699 WP_013175938.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
SLIP_RS08880 1852289..1852639 - 351 WP_041433572.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SLIP_RS08885 1852645..1852896 - 252 WP_148216649.1 ribbon-helix-helix protein, CopG family Antitoxin
SLIP_RS08890 1853004..1854140 - 1137 WP_207635770.1 alanine racemase -
SLIP_RS08895 1854140..1854589 - 450 WP_013175942.1 CBS domain-containing protein -
SLIP_RS08900 1854629..1856182 - 1554 WP_013175943.1 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase -
SLIP_RS08905 1856195..1856566 - 372 WP_013175944.1 holo-ACP synthase -
SLIP_RS08910 1856703..1857182 - 480 WP_013175946.1 chemotaxis protein CheW -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12784.80 Da        Isoelectric Point: 8.4942

>T24785 WP_041433572.1 NC_014220:c1852639-1852289 [Syntrophothermus lipocalidus DSM 12680]
MTIKRGEVYFAQLNPVVGSEQGGIRPVLVVQNDIGNQYSPTTIVLAITSQINKAKLPTHVELRAAKYGLDKDSVILGEQI
RTIDKTRLKQRIAFLDEETMAKVNHALEISLGLVDA

Download         Length: 351 bp

>T24785 NC_014220:c1852639-1852289 [Syntrophothermus lipocalidus DSM 12680]
TTGACAATAAAGCGTGGTGAAGTCTATTTTGCCCAACTCAACCCGGTCGTCGGCTCAGAGCAAGGAGGGATCAGACCGGT
TCTCGTAGTTCAGAACGATATAGGTAATCAGTATAGTCCTACCACCATCGTGTTAGCTATTACATCGCAGATAAACAAGG
CCAAGCTGCCTACGCATGTGGAACTTCGGGCCGCAAAATACGGTCTGGACAAAGATTCGGTCATACTGGGAGAACAGATA
CGCACTATCGACAAGACCAGGCTCAAACAACGGATTGCCTTTTTGGATGAAGAGACCATGGCCAAAGTGAATCACGCCTT
GGAAATAAGCTTGGGATTGGTCGATGCCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9729.33 Da        Isoelectric Point: 4.4243

>AT24785 WP_148216649.1 NC_014220:c1852896-1852645 [Syntrophothermus lipocalidus DSM 12680]
MITVPENLLLELEDIYVAESKNRSEIIREALRMYLGERRKRLINEQMKKGYMEMADINLTLACECSSADYEALIQCLERL
ITE

Download         Length: 252 bp

>AT24785 NC_014220:c1852896-1852645 [Syntrophothermus lipocalidus DSM 12680]
ATGATCACCGTACCGGAAAACCTATTACTGGAGCTGGAGGACATCTACGTTGCCGAGAGCAAAAACCGAAGCGAGATTAT
CCGCGAAGCCCTCAGGATGTACCTGGGGGAGCGCAGGAAAAGACTTATTAACGAGCAGATGAAAAAAGGATACATGGAGA
TGGCCGATATAAACCTGACCCTCGCTTGTGAGTGTTCCTCGGCTGATTACGAGGCCCTGATACAATGTTTAGAAAGGTTA
ATAACGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References