Detailed information of TA system TA247842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 476390..477728
• Replicon: chromosome
• Accession: NZ_CP098710
• Organism: Yersinia ruckeri strain NVI-4479

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: ND012_RS02210
• Protein ID: WP_038275283.1
• Coordinates: 476778..477728 (+)
• Length: 317 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: A0A848MNT5
• Locus tag: ND012_RS02205
• Protein ID: WP_038245317.1
• Coordinates: 476390..476785 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ND012_RS02155 (ND012_02155)	471855..472244	+	390	WP_234049240.1	restriction endonuclease subunit S	-
ND012_RS02160 (ND012_02160)	472368..472943	+	576	WP_234049239.1	DarT ssDNA thymidine ADP-ribosyltransferase family protein	-
ND012_RS02165 (ND012_02165)	472946..473602	+	657	WP_096823271.1	DUF4433 domain-containing protein	-
ND012_RS02170 (ND012_02170)	473599..474666	+	1068	WP_096823272.1	macro domain-containing protein	-
ND012_RS02175 (ND012_02175)	474687..474953	+	267	Protein_421	hypothetical protein	-
ND012_RS02180 (ND012_02180)	474972..475370	-	399	Protein_422	integrase core domain-containing protein	-
ND012_RS02185 (ND012_02185)	475369..475665	+	297	Protein_423	integrase core domain-containing protein	-
ND012_RS02190 (ND012_02190)	475694..475814	-	121	Protein_424	transposase	-
ND012_RS02195 (ND012_02195)	475807..475935	-	129	Protein_425	helix-turn-helix domain-containing protein	-
ND012_RS02200 (ND012_02200)	476085..476315	+	231	Protein_426	DUF4942 domain-containing protein	-
ND012_RS02205 (ND012_02205)	476390..476785	+	396	WP_038245317.1	DUF6088 family protein	Antitoxin
ND012_RS02210 (ND012_02210)	476778..477728	+	951	WP_038275283.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ND012_RS02215 (ND012_02215)	478096..478221	+	126	Protein_429	antirestriction protein	-
ND012_RS02220 (ND012_02220)	478247..478489	+	243	Protein_430	type IV toxin-antitoxin system YeeU family antitoxin	-
ND012_RS02225 (ND012_02225)	479024..480178	+	1155	WP_038245380.1	N-acetylneuraminate epimerase	-
ND012_RS02230 (ND012_02230)	480226..480918	+	693	WP_038245321.1	oligogalacturonate-specific porin KdgM family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	475417..475665	248

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (39-304)

Antitoxin

• Protein of unknown function DUF6088 (10-114)

Sequences

Toxin

Protein

• Length: 317 a.a.
• Molecular weight: 36088.43 Da
• Isoelectric Point: 4.5996

>T247842 WP_038275283.1 NZ_CP098710:476778-477728 [Yersinia ruckeri]
MDDLTKLFPDVADALGIESVSIVEKDYYIVELLRLLQPMDFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPVAGFTQ
QYSRGQRKDIRKGIIRTVIETITASGTFRMDEGYPKVTRDEYRYNEIPVRYPQEYVQVPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGADVPVLKQFV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELVSNPVYKERYLQFVTPMVFGESHVSWEEAYACFRKTVLDVVDA

Nucleotide

• Length: 951 bp

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14406.76 Da
• Isoelectric Point: 11.0360

>AT247842 WP_038245317.1 NZ_CP098710:476390-476785 [Yersinia ruckeri]
MTTKARIQLRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLKVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG

Nucleotide

• Length: 396 bp

Structures

Antitoxin

• AlphaFold DB: A0A848MNT5