Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pmenTA/darT(toxin) |
| Location | 472946..474666 | Replicon | chromosome |
| Accession | NZ_CP098710 | ||
| Organism | Yersinia ruckeri strain NVI-4479 | ||
Toxin (Protein)
| Gene name | pmenT | Uniprot ID | - |
| Locus tag | ND012_RS02165 | Protein ID | WP_096823271.1 |
| Coordinates | 472946..473602 (+) | Length | 219 a.a. |
Antitoxin (Protein)
| Gene name | pmenA | Uniprot ID | - |
| Locus tag | ND012_RS02170 | Protein ID | WP_096823272.1 |
| Coordinates | 473599..474666 (+) | Length | 356 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ND012_RS02135 (ND012_02135) | 468166..469110 | - | 945 | WP_248578899.1 | hypothetical protein | - |
| ND012_RS02140 (ND012_02140) | 469624..470883 | + | 1260 | Protein_414 | integrase arm-type DNA-binding domain-containing protein | - |
| ND012_RS02145 (ND012_02145) | 471057..471311 | + | 255 | WP_005175264.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| ND012_RS02150 (ND012_02150) | 471301..471591 | + | 291 | WP_038275268.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| ND012_RS02155 (ND012_02155) | 471855..472244 | + | 390 | WP_234049240.1 | restriction endonuclease subunit S | - |
| ND012_RS02160 (ND012_02160) | 472368..472943 | + | 576 | WP_234049239.1 | DarT ssDNA thymidine ADP-ribosyltransferase family protein | - |
| ND012_RS02165 (ND012_02165) | 472946..473602 | + | 657 | WP_096823271.1 | DUF4433 domain-containing protein | Toxin |
| ND012_RS02170 (ND012_02170) | 473599..474666 | + | 1068 | WP_096823272.1 | macro domain-containing protein | Antitoxin |
| ND012_RS02175 (ND012_02175) | 474687..474953 | + | 267 | Protein_421 | hypothetical protein | - |
| ND012_RS02180 (ND012_02180) | 474972..475370 | - | 399 | Protein_422 | integrase core domain-containing protein | - |
| ND012_RS02185 (ND012_02185) | 475369..475665 | + | 297 | Protein_423 | integrase core domain-containing protein | - |
| ND012_RS02190 (ND012_02190) | 475694..475814 | - | 121 | Protein_424 | transposase | - |
| ND012_RS02195 (ND012_02195) | 475807..475935 | - | 129 | Protein_425 | helix-turn-helix domain-containing protein | - |
| ND012_RS02200 (ND012_02200) | 476085..476315 | + | 231 | Protein_426 | DUF4942 domain-containing protein | - |
| ND012_RS02205 (ND012_02205) | 476390..476785 | + | 396 | WP_038245317.1 | DUF6088 family protein | - |
| ND012_RS02210 (ND012_02210) | 476778..477728 | + | 951 | WP_038275283.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| ND012_RS02215 (ND012_02215) | 478096..478221 | + | 126 | Protein_429 | antirestriction protein | - |
| ND012_RS02220 (ND012_02220) | 478247..478489 | + | 243 | Protein_430 | type IV toxin-antitoxin system YeeU family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 457945..475665 | 17720 | |
| - | flank | IS/Tn | - | - | 475417..475665 | 248 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 219 a.a. Molecular weight: 25214.72 Da Isoelectric Point: 6.6007
>T247841 WP_096823271.1 NZ_CP098710:472946-473602 [Yersinia ruckeri]
VAYDYSTSLNPEKALIWRIVHRDNIPWILDNGLHCGNSPVQAEDWINIGNPELIDKRAGHLVPTGMRGTLHDYVPFYFTP
FSPMLMNIRSGRGGIKQRPNEEIVILVSSLRNMVAQNVSFVFTDSHAYYNLANYFTELDSLNQIDWPILQARDFRRDQDD
LAKFERYQAEALIWKHCPIALLGGMICYNDGVRLQLEQWLSQRNLSMPVHARAGWYFS
VAYDYSTSLNPEKALIWRIVHRDNIPWILDNGLHCGNSPVQAEDWINIGNPELIDKRAGHLVPTGMRGTLHDYVPFYFTP
FSPMLMNIRSGRGGIKQRPNEEIVILVSSLRNMVAQNVSFVFTDSHAYYNLANYFTELDSLNQIDWPILQARDFRRDQDD
LAKFERYQAEALIWKHCPIALLGGMICYNDGVRLQLEQWLSQRNLSMPVHARAGWYFS
Download Length: 657 bp
Antitoxin
Download Length: 356 a.a. Molecular weight: 40847.21 Da Isoelectric Point: 6.3136
>AT247841 WP_096823272.1 NZ_CP098710:473599-474666 [Yersinia ruckeri]
MITFTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPVNMKAYALACKHKQVMTGKMFITETGELMGPRWIVNFPTK
QHWRADSRMEWVEDGLQDLRRFLIEEKVQSIAIPPLGAGNGGLNWSDVRMRIESALGDLQDTEILIYEPTEKYQNVAKST
GVKKLTPARALIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQEDVLKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDTQPLDVIWFNDQEKEHINLWLNNEAKEWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGKCQPTLDSVKEG
LHQWPAGERWASRKMKLFDDKNLQFAINRVMEFHC
MITFTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPVNMKAYALACKHKQVMTGKMFITETGELMGPRWIVNFPTK
QHWRADSRMEWVEDGLQDLRRFLIEEKVQSIAIPPLGAGNGGLNWSDVRMRIESALGDLQDTEILIYEPTEKYQNVAKST
GVKKLTPARALIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQEDVLKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDTQPLDVIWFNDQEKEHINLWLNNEAKEWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGKCQPTLDSVKEG
LHQWPAGERWASRKMKLFDDKNLQFAINRVMEFHC
Download Length: 1068 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|