Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1877247..1878165 Replicon chromosome
Accession NZ_CP098706
Organism Yersinia ruckeri strain NVI-4570

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag ND447_RS08435 Protein ID WP_038242633.1
Coordinates 1877707..1878165 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A085U7R3
Locus tag ND447_RS08430 Protein ID WP_038242631.1
Coordinates 1877247..1877693 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND447_RS08410 (ND447_08400) 1872945..1873649 + 705 WP_004717543.1 murein tripeptide amidase MpaA -
ND447_RS08415 (ND447_08405) 1873660..1874634 - 975 WP_071706618.1 L-Ala-D/L-Glu epimerase -
ND447_RS08420 (ND447_08410) 1874784..1875287 + 504 WP_004717547.1 thiol peroxidase -
ND447_RS08425 (ND447_08415) 1875322..1876929 - 1608 WP_096823414.1 transcriptional regulator TyrR -
ND447_RS08430 (ND447_08420) 1877247..1877693 + 447 WP_038242631.1 DUF2384 domain-containing protein Antitoxin
ND447_RS08435 (ND447_08425) 1877707..1878165 + 459 WP_038242633.1 RES domain-containing protein Toxin
ND447_RS08440 (ND447_08430) 1878169..1879227 - 1059 WP_038242635.1 YcjF family protein -
ND447_RS08445 (ND447_08435) 1879224..1880621 - 1398 WP_004717556.1 YcjX family protein -
ND447_RS08450 (ND447_08440) 1880602..1880844 - 243 WP_096823415.1 phage shock protein PspD -
ND447_RS08455 (ND447_08445) 1880908..1881267 - 360 WP_004717559.1 envelope stress response membrane protein PspC -
ND447_RS08460 (ND447_08450) 1881267..1881494 - 228 WP_038242637.1 envelope stress response membrane protein PspB -
ND447_RS08465 (ND447_08455) 1881578..1882243 - 666 WP_038275968.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17072.55 Da        Isoelectric Point: 6.6384

>T247831 WP_038242633.1 NZ_CP098706:1877707-1878165 [Yersinia ruckeri]
VMLYRIVHNRYLATAWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHVEDSATLNDFNLFQITIPDNAIMVLQQQ
DWPRGWRDDPTPVATMDIGTEWIGSVSSVGLLVPSTLVPLERNMLVNPKHRDFASCLKSINPLTFSFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16406.87 Da        Isoelectric Point: 8.0956

>AT247831 WP_038242631.1 NZ_CP098706:1877247-1877693 [Yersinia ruckeri]
MRTYHPSPMAKVSALWREIGLPASRGTALVDSIKLGFTVDVIDTIHLWADMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDRTKATAWMSMPVKGLGNRTPDSLLETETGALEICDLIGRLEHGVFS

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A085U7R3

References