247825

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 3122655..3123993 Replicon chromosome
Accession NZ_CP098703
Organism Yersinia ruckeri strain NVI-4840

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag ND437_RS14280 Protein ID WP_038275283.1
Coordinates 3122655..3123605 (-) Length 317 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A848MNT5
Locus tag ND437_RS14285 Protein ID WP_038245317.1
Coordinates 3123598..3123993 (-) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND437_RS14260 (ND437_14250) 3119466..3120158 - 693 WP_038245321.1 oligogalacturonate-specific porin KdgM family protein -
ND437_RS14265 (ND437_14255) 3120206..3121360 - 1155 WP_038245380.1 N-acetylneuraminate epimerase -
ND437_RS14270 (ND437_14260) 3121963..3122136 - 174 Protein_2773 type IV toxin-antitoxin system YeeU family antitoxin -
ND437_RS14275 (ND437_14265) 3122162..3122287 - 126 Protein_2774 antirestriction protein -
ND437_RS14280 (ND437_14270) 3122655..3123605 - 951 WP_038275283.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
ND437_RS14285 (ND437_14275) 3123598..3123993 - 396 WP_038245317.1 DUF6088 family protein Antitoxin
ND437_RS14290 (ND437_14280) 3124068..3124298 - 231 Protein_2777 DUF4942 domain-containing protein -
ND437_RS14295 (ND437_14285) 3124448..3124576 + 129 Protein_2778 helix-turn-helix domain-containing protein -
ND437_RS14300 (ND437_14290) 3124569..3124689 + 121 Protein_2779 transposase -
ND437_RS14305 (ND437_14295) 3124718..3125014 - 297 Protein_2780 integrase core domain-containing protein -
ND437_RS14310 (ND437_14300) 3125013..3125411 + 399 Protein_2781 integrase core domain-containing protein -
ND437_RS14315 (ND437_14305) 3125430..3125696 - 267 Protein_2782 hypothetical protein -
ND437_RS14320 (ND437_14310) 3125717..3126784 - 1068 WP_096823272.1 macro domain-containing protein -
ND437_RS14325 (ND437_14315) 3126781..3127437 - 657 WP_096823271.1 DUF4433 domain-containing protein -
ND437_RS14330 (ND437_14320) 3127440..3128015 - 576 WP_234049239.1 DarT ssDNA thymidine ADP-ribosyltransferase family protein -
ND437_RS14335 (ND437_14325) 3128139..3128528 - 390 WP_234049240.1 restriction endonuclease subunit S -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3124718..3124966 248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 317 a.a.        Molecular weight: 36088.43 Da        Isoelectric Point: 4.5996

>T247825 WP_038275283.1 NZ_CP098703:c3123605-3122655 [Yersinia ruckeri]
MDDLTKLFPDVADALGIESVSIVEKDYYIVELLRLLQPMDFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPVAGFTQ
QYSRGQRKDIRKGIIRTVIETITASGTFRMDEGYPKVTRDEYRYNEIPVRYPQEYVQVPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGADVPVLKQFV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELVSNPVYKERYLQFVTPMVFGESHVSWEEAYACFRKTVLDVVDA

Download         Length: 951 bp


Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14406.76 Da        Isoelectric Point: 11.0360

>AT247825 WP_038245317.1 NZ_CP098703:c3123993-3123598 [Yersinia ruckeri]
MTTKARIQLRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLKVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG

Download         Length: 396 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A848MNT5

References