Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2633022..2633645 Replicon chromosome
Accession NZ_CP098703
Organism Yersinia ruckeri strain NVI-4840

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag ND437_RS12125 Protein ID WP_038243726.1
Coordinates 2633442..2633645 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag ND437_RS12120 Protein ID WP_004718732.1
Coordinates 2633022..2633390 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND437_RS12105 (ND437_12100) 2631276..2631530 + 255 WP_038243728.1 type B 50S ribosomal protein L31 -
ND437_RS12110 (ND437_12105) 2631550..2631693 + 144 WP_004718738.1 type B 50S ribosomal protein L36 -
ND437_RS12115 (ND437_12110) 2631812..2631973 - 162 WP_004718735.1 hypothetical protein -
ND437_RS12120 (ND437_12115) 2633022..2633390 + 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
ND437_RS12125 (ND437_12120) 2633442..2633645 + 204 WP_038243726.1 expression modulating protein YmoA Toxin
ND437_RS12135 (ND437_12130) 2634454..2634768 + 315 WP_248577445.1 MGMT family protein -
ND437_RS12140 (ND437_12135) 2635146..2636009 + 864 WP_004718726.1 acyl-CoA thioesterase II -
ND437_RS12145 (ND437_12140) 2636124..2637413 - 1290 WP_004718723.1 ammonium transporter AmtB -
ND437_RS12150 (ND437_12145) 2637452..2637790 - 339 WP_007886947.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T247824 WP_038243726.1 NZ_CP098703:2633442-2633645 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT247824 WP_004718732.1 NZ_CP098703:2633022-2633390 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References