Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 3189411..3190749 | Replicon | chromosome |
| Accession | NZ_CP098701 | ||
| Organism | Yersinia ruckeri strain NVI-5089 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | - |
| Locus tag | ND440_RS14670 | Protein ID | WP_038275283.1 |
| Coordinates | 3189411..3190361 (-) | Length | 317 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | A0A848MNT5 |
| Locus tag | ND440_RS14675 | Protein ID | WP_038245317.1 |
| Coordinates | 3190354..3190749 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ND440_RS14650 (ND440_14645) | 3186222..3186914 | - | 693 | WP_038245321.1 | oligogalacturonate-specific porin KdgM family protein | - |
| ND440_RS14655 (ND440_14650) | 3186962..3188116 | - | 1155 | WP_038245380.1 | N-acetylneuraminate epimerase | - |
| ND440_RS14660 (ND440_14655) | 3188719..3188892 | - | 174 | Protein_2840 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| ND440_RS14665 (ND440_14660) | 3188918..3189043 | - | 126 | Protein_2841 | antirestriction protein | - |
| ND440_RS14670 (ND440_14665) | 3189411..3190361 | - | 951 | WP_038275283.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| ND440_RS14675 (ND440_14670) | 3190354..3190749 | - | 396 | WP_038245317.1 | DUF6088 family protein | Antitoxin |
| ND440_RS14680 (ND440_14675) | 3190824..3191054 | - | 231 | Protein_2844 | DUF4942 domain-containing protein | - |
| ND440_RS14685 (ND440_14680) | 3191204..3191332 | + | 129 | Protein_2845 | helix-turn-helix domain-containing protein | - |
| ND440_RS14690 (ND440_14685) | 3191325..3191445 | + | 121 | Protein_2846 | transposase | - |
| ND440_RS14695 (ND440_14690) | 3191474..3191770 | - | 297 | Protein_2847 | integrase core domain-containing protein | - |
| ND440_RS14700 (ND440_14695) | 3191769..3192167 | + | 399 | Protein_2848 | integrase core domain-containing protein | - |
| ND440_RS14705 (ND440_14700) | 3192186..3192452 | - | 267 | Protein_2849 | hypothetical protein | - |
| ND440_RS14710 (ND440_14705) | 3192473..3193540 | - | 1068 | WP_096823272.1 | macro domain-containing protein | - |
| ND440_RS14715 (ND440_14710) | 3193537..3194193 | - | 657 | WP_096823271.1 | DUF4433 domain-containing protein | - |
| ND440_RS14720 (ND440_14715) | 3194196..3194771 | - | 576 | WP_234049239.1 | DarT ssDNA thymidine ADP-ribosyltransferase family protein | - |
| ND440_RS14725 (ND440_14720) | 3194895..3195284 | - | 390 | WP_234049240.1 | restriction endonuclease subunit S | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3186962..3201094 | 14132 | |
| - | inside | IScluster/Tn | - | - | 3191474..3197377 | 5903 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 317 a.a. Molecular weight: 36088.43 Da Isoelectric Point: 4.5996
>T247814 WP_038275283.1 NZ_CP098701:c3190361-3189411 [Yersinia ruckeri]
MDDLTKLFPDVADALGIESVSIVEKDYYIVELLRLLQPMDFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPVAGFTQ
QYSRGQRKDIRKGIIRTVIETITASGTFRMDEGYPKVTRDEYRYNEIPVRYPQEYVQVPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGADVPVLKQFV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELVSNPVYKERYLQFVTPMVFGESHVSWEEAYACFRKTVLDVVDA
MDDLTKLFPDVADALGIESVSIVEKDYYIVELLRLLQPMDFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPVAGFTQ
QYSRGQRKDIRKGIIRTVIETITASGTFRMDEGYPKVTRDEYRYNEIPVRYPQEYVQVPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGADVPVLKQFV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELVSNPVYKERYLQFVTPMVFGESHVSWEEAYACFRKTVLDVVDA
Download Length: 951 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14406.76 Da Isoelectric Point: 11.0360
>AT247814 WP_038245317.1 NZ_CP098701:c3190749-3190354 [Yersinia ruckeri]
MTTKARIQLRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLKVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG
MTTKARIQLRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLKVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|