Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 937779..938402 Replicon chromosome
Accession NZ_CP098701
Organism Yersinia ruckeri strain NVI-5089

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag ND440_RS04145 Protein ID WP_038243726.1
Coordinates 937779..937982 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag ND440_RS04150 Protein ID WP_004718732.1
Coordinates 938034..938402 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND440_RS04120 (ND440_04120) 933634..933972 + 339 WP_007886947.1 P-II family nitrogen regulator -
ND440_RS04125 (ND440_04125) 934011..935300 + 1290 WP_004718723.1 ammonium transporter AmtB -
ND440_RS04130 (ND440_04130) 935415..936278 - 864 WP_004718726.1 acyl-CoA thioesterase II -
ND440_RS04135 (ND440_04135) 936656..936970 - 315 WP_248577445.1 MGMT family protein -
ND440_RS04145 (ND440_04145) 937779..937982 - 204 WP_038243726.1 expression modulating protein YmoA Toxin
ND440_RS04150 (ND440_04150) 938034..938402 - 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
ND440_RS04155 (ND440_04155) 939451..939612 + 162 WP_004718735.1 hypothetical protein -
ND440_RS04160 (ND440_04160) 939731..939874 - 144 WP_004718738.1 type B 50S ribosomal protein L36 -
ND440_RS04165 (ND440_04165) 939894..940148 - 255 WP_038243728.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T247808 WP_038243726.1 NZ_CP098701:c937982-937779 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT247808 WP_004718732.1 NZ_CP098701:c938402-938034 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References