Detailed information of TA system TA024780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2546039..2546625
• Replicon: chromosome
• Accession: NC_014216
• Organism: Desulfurivibrio alkaliphilus AHT2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DAAHT2_RS14440
• Protein ID: WP_013164367.1
• Coordinates: 2546371..2546625 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: D6Z685
• Locus tag: DAAHT2_RS11085
• Protein ID: WP_013164366.1
• Coordinates: 2546039..2546374 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAAHT2_RS14430	2541542..2541958	-	417	WP_083774429.1	helix-turn-helix transcriptional regulator	-
DAAHT2_RS14435	2542098..2542373	+	276	WP_083774431.1	helix-turn-helix domain-containing protein	-
DAAHT2_RS14025	2542377..2543231	+	855	WP_013164362.1	helix-turn-helix domain-containing protein	-
DAAHT2_RS11070	2543325..2544236	+	912	WP_013164363.1	site-specific integrase	-
DAAHT2_RS11075	2544801..2545358	+	558	WP_013164364.1	hypothetical protein	-
DAAHT2_RS11080	2545315..2545896	+	582	WP_013164365.1	hypothetical protein	-
DAAHT2_RS11085	2546039..2546374	-	336	WP_013164366.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DAAHT2_RS14440	2546371..2546625	-	255	WP_013164367.1	type II toxin-antitoxin system HicA family toxin	Toxin
DAAHT2_RS14445	2547102..2548184	+	1083	WP_157861591.1	DNA cytosine methyltransferase	-
DAAHT2_RS11095	2548174..2549838	+	1665	WP_013164369.1	ATP-binding protein	-
DAAHT2_RS11100	2549982..2550581	+	600	WP_013164370.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2543325..2556217	12892
	-	flank	IS/Tn	-	-	2550956..2551741	785

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9503.91 Da
• Isoelectric Point: 10.9032

>T24780 WP_013164367.1 NC_014216:c2546625-2546371 [Desulfurivibrio alkaliphilus AHT 2]
MNSRHHHTLASIFAKPTPTGIEWRRIEALFKALGAEVIEGDGSRVAFILKGEKGDFHRPHPAKEAKRYQVRDARDFLTRA
GIKP

Nucleotide

• Length: 255 bp

>T24780 NC_014216:c2546625-2546371 [Desulfurivibrio alkaliphilus AHT 2]
ATGAACAGCAGACATCACCATACACTTGCCTCCATTTTTGCCAAGCCGACTCCGACCGGCATTGAGTGGAGACGCATTGA
AGCCTTGTTCAAGGCCCTGGGCGCCGAGGTTATTGAAGGTGATGGTTCGCGGGTAGCCTTTATCCTCAAAGGCGAAAAAG
GAGACTTCCATAGACCGCATCCAGCCAAGGAAGCGAAACGCTATCAGGTTCGTGACGCCAGAGATTTTTTAACAAGAGCG
GGGATCAAGCCATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12245.82 Da
• Isoelectric Point: 6.7555

>AT24780 WP_013164366.1 NC_014216:c2546374-2546039 [Desulfurivibrio alkaliphilus AHT 2]
MNTLKHRGYTAKIDFDPEDNIFFGHLLGIRDTVGFHGETAAELKKAFVEAVDFYIESCEKAGRKPEKPFSGRFVVRVDSS
LHAEIAATAAAAGKSINKWVAETLDQAIHSH

Nucleotide

• Length: 336 bp

>AT24780 NC_014216:c2546374-2546039 [Desulfurivibrio alkaliphilus AHT 2]
ATGAATACTCTTAAACACAGGGGATACACCGCCAAAATAGACTTTGACCCCGAGGACAACATTTTTTTTGGACACCTTCT
TGGCATTCGTGACACGGTTGGTTTTCACGGCGAAACTGCCGCTGAGTTGAAGAAGGCCTTTGTTGAAGCGGTGGATTTTT
ATATTGAGAGCTGCGAGAAGGCCGGCCGAAAACCGGAAAAACCCTTTTCCGGCCGTTTCGTGGTTCGAGTCGATTCGTCC
TTGCACGCCGAAATTGCCGCCACTGCTGCGGCCGCCGGCAAAAGCATCAACAAGTGGGTAGCCGAAACCCTTGATCAGGC
GATACACTCCCACTAA

Structures

Antitoxin

• AlphaFold DB: D6Z685