Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2546039..2546625 Replicon chromosome
Accession NC_014216
Organism Desulfurivibrio alkaliphilus AHT2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DAAHT2_RS14440 Protein ID WP_013164367.1
Coordinates 2546371..2546625 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D6Z685
Locus tag DAAHT2_RS11085 Protein ID WP_013164366.1
Coordinates 2546039..2546374 (-) Length 112 a.a.

Genomic Context

DAAHT2_RS14435DAAHT2_RS14025DAAHT2_RS11070DAAHT2_RS11075DAAHT2_RS11080DAAHT2_RS14445DAAHT2_RS11095DAAHT2_RS11100DAAHT2_RS14430DAAHT2_RS11085DAAHT2_RS14440
Location: 2542098..2542373 (276 bp)
Type: Others
Protein ID: WP_083774431.1
Location: 2542377..2543231 (855 bp)
Type: Others
Protein ID: WP_013164362.1
Location: 2543325..2544236 (912 bp)
Type: Others
Protein ID: WP_013164363.1
Location: 2544801..2545358 (558 bp)
Type: Others
Protein ID: WP_013164364.1
Location: 2545315..2545896 (582 bp)
Type: Others
Protein ID: WP_013164365.1
Location: 2547102..2548184 (1083 bp)
Type: Others
Protein ID: WP_157861591.1
Location: 2548174..2549838 (1665 bp)
Type: Others
Protein ID: WP_013164369.1
Location: 2549982..2550581 (600 bp)
Type: Others
Protein ID: WP_013164370.1
Location: 2541542..2541958 (417 bp)
Type: Others
Protein ID: WP_083774429.1
Location: 2546039..2546374 (336 bp)
Type: Antitoxin
Protein ID: WP_013164366.1
Location: 2546371..2546625 (255 bp)
Type: Toxin
Protein ID: WP_013164367.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DAAHT2_RS144302541542..2541958-417WP_083774429.1helix-turn-helix transcriptional regulator-
DAAHT2_RS144352542098..2542373+276WP_083774431.1helix-turn-helix domain-containing protein-
DAAHT2_RS140252542377..2543231+855WP_013164362.1helix-turn-helix domain-containing protein-
DAAHT2_RS110702543325..2544236+912WP_013164363.1site-specific integrase-
DAAHT2_RS110752544801..2545358+558WP_013164364.1hypothetical protein-
DAAHT2_RS110802545315..2545896+582WP_013164365.1hypothetical protein-
DAAHT2_RS110852546039..2546374-336WP_013164366.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
DAAHT2_RS144402546371..2546625-255WP_013164367.1type II toxin-antitoxin system HicA family toxinToxin
DAAHT2_RS144452547102..2548184+1083WP_157861591.1DNA cytosine methyltransferase-
DAAHT2_RS110952548174..2549838+1665WP_013164369.1ATP-binding protein-
DAAHT2_RS111002549982..2550581+600WP_013164370.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--2543325..255621712892
-flankIS/Tn--2550956..2551741785


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9503.91 Da        Isoelectric Point: 10.9032

>T24780 WP_013164367.1 NC_014216:c2546625-2546371 [Desulfurivibrio alkaliphilus AHT 2]
MNSRHHHTLASIFAKPTPTGIEWRRIEALFKALGAEVIEGDGSRVAFILKGEKGDFHRPHPAKEAKRYQVRDARDFLTRA
GIKP

Download         Length: 255 bp

>T24780 NC_014216:c2546625-2546371 [Desulfurivibrio alkaliphilus AHT 2]
ATGAACAGCAGACATCACCATACACTTGCCTCCATTTTTGCCAAGCCGACTCCGACCGGCATTGAGTGGAGACGCATTGA
AGCCTTGTTCAAGGCCCTGGGCGCCGAGGTTATTGAAGGTGATGGTTCGCGGGTAGCCTTTATCCTCAAAGGCGAAAAAG
GAGACTTCCATAGACCGCATCCAGCCAAGGAAGCGAAACGCTATCAGGTTCGTGACGCCAGAGATTTTTTAACAAGAGCG
GGGATCAAGCCATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12245.82 Da        Isoelectric Point: 6.7555

>AT24780 WP_013164366.1 NC_014216:c2546374-2546039 [Desulfurivibrio alkaliphilus AHT 2]
MNTLKHRGYTAKIDFDPEDNIFFGHLLGIRDTVGFHGETAAELKKAFVEAVDFYIESCEKAGRKPEKPFSGRFVVRVDSS
LHAEIAATAAAAGKSINKWVAETLDQAIHSH

Download         Length: 336 bp

>AT24780 NC_014216:c2546374-2546039 [Desulfurivibrio alkaliphilus AHT 2]
ATGAATACTCTTAAACACAGGGGATACACCGCCAAAATAGACTTTGACCCCGAGGACAACATTTTTTTTGGACACCTTCT
TGGCATTCGTGACACGGTTGGTTTTCACGGCGAAACTGCCGCTGAGTTGAAGAAGGCCTTTGTTGAAGCGGTGGATTTTT
ATATTGAGAGCTGCGAGAAGGCCGGCCGAAAACCGGAAAAACCCTTTTCCGGCCGTTTCGTGGTTCGAGTCGATTCGTCC
TTGCACGCCGAAATTGCCGCCACTGCTGCGGCCGCCGGCAAAAGCATCAACAAGTGGGTAGCCGAAACCCTTGATCAGGC
GATACACTCCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBD6Z685

References