Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1877792..1878710 Replicon chromosome
Accession NZ_CP098697
Organism Yersinia ruckeri strain NVI-6614

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag ND449_RS08410 Protein ID WP_038242633.1
Coordinates 1878252..1878710 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A085U7R3
Locus tag ND449_RS08405 Protein ID WP_038242631.1
Coordinates 1877792..1878238 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND449_RS08385 (ND449_08375) 1873490..1874194 + 705 WP_004717543.1 murein tripeptide amidase MpaA -
ND449_RS08390 (ND449_08380) 1874205..1875179 - 975 WP_071706618.1 L-Ala-D/L-Glu epimerase -
ND449_RS08395 (ND449_08385) 1875329..1875832 + 504 WP_004717547.1 thiol peroxidase -
ND449_RS08400 (ND449_08390) 1875867..1877474 - 1608 WP_096823414.1 transcriptional regulator TyrR -
ND449_RS08405 (ND449_08395) 1877792..1878238 + 447 WP_038242631.1 DUF2384 domain-containing protein Antitoxin
ND449_RS08410 (ND449_08400) 1878252..1878710 + 459 WP_038242633.1 RES domain-containing protein Toxin
ND449_RS08415 (ND449_08405) 1878714..1879772 - 1059 WP_038242635.1 YcjF family protein -
ND449_RS08420 (ND449_08410) 1879769..1881166 - 1398 WP_004717556.1 YcjX family protein -
ND449_RS08425 (ND449_08415) 1881147..1881389 - 243 WP_096823415.1 phage shock protein PspD -
ND449_RS08430 (ND449_08420) 1881453..1881812 - 360 WP_004717559.1 envelope stress response membrane protein PspC -
ND449_RS08435 (ND449_08425) 1881812..1882039 - 228 WP_038242637.1 envelope stress response membrane protein PspB -
ND449_RS08440 (ND449_08430) 1882123..1882788 - 666 WP_038275968.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17072.55 Da        Isoelectric Point: 6.6384

>T247797 WP_038242633.1 NZ_CP098697:1878252-1878710 [Yersinia ruckeri]
VMLYRIVHNRYLATAWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHVEDSATLNDFNLFQITIPDNAIMVLQQQ
DWPRGWRDDPTPVATMDIGTEWIGSVSSVGLLVPSTLVPLERNMLVNPKHRDFASCLKSINPLTFSFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16406.87 Da        Isoelectric Point: 8.0956

>AT247797 WP_038242631.1 NZ_CP098697:1877792-1878238 [Yersinia ruckeri]
MRTYHPSPMAKVSALWREIGLPASRGTALVDSIKLGFTVDVIDTIHLWADMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDRTKATAWMSMPVKGLGNRTPDSLLETETGALEICDLIGRLEHGVFS

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A085U7R3

References