247780

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 3122607..3123945 Replicon chromosome
Accession NZ_CP098694
Organism Yersinia ruckeri strain NVI-8270

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag ND446_RS14065 Protein ID WP_234055605.1
Coordinates 3122607..3123557 (-) Length 317 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A848MNT5
Locus tag ND446_RS14070 Protein ID WP_038245317.1
Coordinates 3123550..3123945 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND446_RS14045 (ND446_14035) 3119406..3120098 - 693 WP_038245321.1 oligogalacturonate-specific porin KdgM family protein -
ND446_RS14050 (ND446_14040) 3120146..3121300 - 1155 WP_038245380.1 N-acetylneuraminate epimerase -
ND446_RS14055 (ND446_14045) 3121903..3122076 - 174 Protein_2719 type IV toxin-antitoxin system YeeU family antitoxin -
ND446_RS14060 (ND446_14050) 3122102..3122227 - 126 Protein_2720 antirestriction protein -
ND446_RS14065 (ND446_14055) 3122607..3123557 - 951 WP_234055605.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
ND446_RS14070 (ND446_14060) 3123550..3123945 - 396 WP_038245317.1 DUF6088 family protein Antitoxin
ND446_RS14075 (ND446_14065) 3124020..3124250 - 231 Protein_2723 DUF4942 domain-containing protein -
ND446_RS14080 (ND446_14070) 3124400..3124528 + 129 Protein_2724 helix-turn-helix domain-containing protein -
ND446_RS14085 (ND446_14075) 3124521..3124641 + 121 Protein_2725 transposase -
ND446_RS14090 (ND446_14080) 3124670..3124966 - 297 Protein_2726 integrase core domain-containing protein -
ND446_RS14095 (ND446_14085) 3124965..3125363 + 399 Protein_2727 integrase core domain-containing protein -
ND446_RS14100 (ND446_14090) 3125382..3125648 - 267 Protein_2728 hypothetical protein -
ND446_RS14105 (ND446_14095) 3125669..3126736 - 1068 WP_096823272.1 macro domain-containing protein -
ND446_RS14110 (ND446_14100) 3126733..3127389 - 657 WP_096823271.1 DUF4433 domain-containing protein -
ND446_RS14115 (ND446_14105) 3127392..3127967 - 576 WP_234049239.1 DarT ssDNA thymidine ADP-ribosyltransferase family protein -
ND446_RS14120 (ND446_14110) 3128091..3128480 - 390 WP_234056964.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(39-304)

Antitoxin

Protein of unknown function DUF6088

(10-114)


Sequences

Toxin        


Download         Length: 317 a.a.        Molecular weight: 36013.34 Da        Isoelectric Point: 4.5092

>T247780 WP_234055605.1 NZ_CP098694:c3123557-3122607 [Yersinia ruckeri]
MDDLTKLFPDVADALGIESVSIVEKDYYIVELLRLLQPMDFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPLAGFSQ
QYSRGQRKSIRKGIIQTIIETVAASGTFLLDEEYPKVTRDEYRYNEIPVRYPQEYVQVPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGADVPVLKQFV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELVSNPVYKERYLQFVTPMVFGESHVSWEEAYACFRKTVLDVVDA

Download         Length: 951 bp

>T247780 NZ_CP098694:c3123557-3122607 [Yersinia ruckeri]
ATGGATGATTTAACAAAGCTATTCCCAGATGTTGCTGATGCTCTGGGCATTGAATCTGTTTCAATTGTAGAAAAAGATTA
TTACATCGTTGAGTTATTACGATTGCTCCAGCCTATGGACTTTGACACGCATCAGCTGGTTTTTGCCGGTGGAACAGCAT
TGTCAAAAGCGGGTATATCTTTGAACAGGATGTCGGAGGACGTGGACATTAAGCTTGTACCTCTCGCCGGTTTTTCCCAG
CAATATTCCAGAGGTCAGCGTAAAAGCATCCGTAAGGGTATTATTCAGACCATTATCGAGACGGTTGCCGCCTCAGGTAC
GTTTCTCCTGGATGAAGAGTATCCAAAGGTTACTCGTGATGAATACCGTTATAATGAAATTCCGGTGCGTTACCCGCAGG
AATATGTACAAGTTCCCTGCTTAAGGCCATTTATCAAACTGGAACTGATGGAAACGGATTTGCTTGAGGCTGCGGAAAAT
CGTGCTATTAGCTCCTTGGTAATGGATCTAACAAAGAAGGGCGAAGTAGTGAGGGCTTTCCCTTGCGCAACCATCGGTAG
CACGCAGGCTGAAAAACTGATCTCGATGATGCGCAGAACGGCTGCAAGTATGCGTGATGTGGAACGTGCAGTGGATGAAT
CACTGGTACGTCATATCTACGATAATTTTTGTATTGTTAGAGAAAAAGGTGCTGACGTTCCTGTTTTGAAGCAATTCGTG
CAGGAATGCATTGAACAGGATATTGAACGTTACGGTGCTCAGTACCCTGAATTCTGCGAGTCGCCTGTCGAAGAACTAAA
AATGGGGCTGGAAGAACTCGTGAGCAATCCTGTTTATAAGGAACGCTATCTGCAATTCGTCACACCAATGGTCTTCGGTG
AAAGCCACGTTTCATGGGAAGAGGCCTATGCCTGTTTTCGCAAAACGGTATTGGATGTGGTTGATGCATAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14406.76 Da        Isoelectric Point: 11.0360

>AT247780 WP_038245317.1 NZ_CP098694:c3123945-3123550 [Yersinia ruckeri]
MTTKARIQLRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLKVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG

Download         Length: 396 bp

>AT247780 NZ_CP098694:c3123945-3123550 [Yersinia ruckeri]
ATGACTACAAAAGCTCGTATTCAGTTACGACTGAAACGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGCTACGACCAAATTGGTAGAGCACTGCGTGAACTGGTGAAGGAAGGGCAGCTGCTGAAAGTAGGCTATGGCGTCT
ACACCAAAGCGCGGCAAAATGTGATTACCGGTAAGTTGATGCCTGCGGCTCCCGGAGGTTCGGCTGCGGTAGTGATTGAG
GCGTTGGAACGTCTGAAAGTGGATTACCGCTTGGTTGGAGCAACAAGCGCCTATAATAGCGGTAAATCCACTCAGATCCC
CGCTTCACTGGAAATCAAAACCTCACCACGTTTTAAGAGGACATTGTCAGTAGGGAGCAGCAAACTAAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A848MNT5

References