Detailed information of TA system TA024778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1196948..1197584
• Replicon: chromosome
• Accession: NC_014216
• Organism: Desulfurivibrio alkaliphilus AHT2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DAAHT2_RS05095
• Protein ID: WP_041719391.1
• Coordinates: 1196948..1197202 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DAAHT2_RS05100
• Protein ID: WP_013163230.1
• Coordinates: 1197213..1197584 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAAHT2_RS05080	1192274..1192930	+	657	WP_157861418.1	TetR/AcrR family transcriptional regulator	-
DAAHT2_RS05085	1192987..1193403	+	417	WP_013163227.1	hypothetical protein	-
DAAHT2_RS05090	1193459..1196707	-	3249	WP_013163228.1	type I restriction endonuclease subunit R	-
DAAHT2_RS05095	1196948..1197202	+	255	WP_041719391.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DAAHT2_RS05100	1197213..1197584	+	372	WP_013163230.1	helix-turn-helix domain-containing protein	Antitoxin
DAAHT2_RS05105	1197704..1198900	-	1197	WP_049824364.1	ATP-binding protein	-
DAAHT2_RS05110	1199033..1199818	-	786	WP_013163231.1	IS21-like element helper ATPase IstB	-
DAAHT2_RS14240	1199834..1201128	-	1295	Protein_1001	transposase	-
DAAHT2_RS14245	1201308..1201478	-	171	WP_083774379.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1199033..1199818	785

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-79)

Antitoxin

• Cro/C1-type helix-turn-helix domain (69-122)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9301.82 Da
• Isoelectric Point: 10.8966

>T24778 WP_041719391.1 NC_014216:1196948-1197202 [Desulfurivibrio alkaliphilus AHT 2]
MKRLTYSRDALKTLGRIPADTARLIRSKLEQYAAEPASLTNNVKAIKGQPGYLRLRIGDWRVIFSDNGEVIAVIKLAPRG
GAYS

Nucleotide

• Length: 255 bp

>T24778 NC_014216:1196948-1197202 [Desulfurivibrio alkaliphilus AHT 2]
ATGAAGAGACTCACCTACAGCCGGGACGCCTTGAAAACACTGGGACGAATACCCGCCGACACCGCCCGCTTGATCCGGTC
AAAACTTGAACAGTACGCGGCGGAACCGGCAAGCCTGACCAACAACGTCAAAGCTATTAAAGGCCAACCAGGCTATCTTC
GGCTCCGCATTGGCGACTGGCGGGTGATTTTTTCGGATAACGGCGAAGTTATCGCCGTCATTAAGCTCGCGCCGCGTGGC
GGCGCTTACAGTTAG

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13695.56 Da
• Isoelectric Point: 4.4969

>AT24778 WP_013163230.1 NC_014216:1197213-1197584 [Desulfurivibrio alkaliphilus AHT 2]
MHEQIIITAGGERLVVIPEADYLAMLDAIEDREDIAAIEKFHRRLAAGEEELLPAEMANRILDGENKIRVWREYRGMSAR
ELASTAQISTSYLSQVETGSREGGIDTLKRIAAALRVSIDDLV

Nucleotide

• Length: 372 bp

>AT24778 NC_014216:1197213-1197584 [Desulfurivibrio alkaliphilus AHT 2]
ATGCACGAACAGATTATCATCACCGCCGGGGGAGAACGCCTGGTTGTAATTCCCGAGGCCGATTACCTTGCCATGCTCGA
CGCCATTGAAGATCGCGAGGATATCGCGGCCATTGAAAAATTCCACCGCCGACTTGCGGCAGGTGAAGAGGAACTGCTGC
CCGCCGAAATGGCCAATCGCATCCTTGACGGCGAAAACAAAATCCGGGTCTGGCGGGAGTATCGAGGGATGTCGGCACGC
GAGCTGGCCTCCACGGCGCAGATAAGCACTTCCTATCTGTCGCAGGTCGAAACCGGCTCCCGCGAAGGCGGTATCGATAC
GCTCAAACGCATAGCCGCCGCCCTTCGCGTATCAATCGATGATCTCGTGTGA