Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2634569..2635192 Replicon chromosome
Accession NZ_CP098694
Organism Yersinia ruckeri strain NVI-8270

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag ND446_RS11935 Protein ID WP_038243726.1
Coordinates 2634989..2635192 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag ND446_RS11930 Protein ID WP_004718732.1
Coordinates 2634569..2634937 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND446_RS11915 (ND446_11915) 2632822..2633076 + 255 WP_038243728.1 type B 50S ribosomal protein L31 -
ND446_RS11920 (ND446_11920) 2633096..2633239 + 144 WP_004718738.1 type B 50S ribosomal protein L36 -
ND446_RS11925 (ND446_11925) 2633358..2633495 - 138 WP_186368427.1 hypothetical protein -
ND446_RS11930 (ND446_11930) 2634569..2634937 + 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
ND446_RS11935 (ND446_11935) 2634989..2635192 + 204 WP_038243726.1 expression modulating protein YmoA Toxin
ND446_RS11945 (ND446_11945) 2636001..2636315 + 315 WP_004718728.1 MGMT family protein -
ND446_RS11950 (ND446_11950) 2636693..2637556 + 864 WP_004718726.1 acyl-CoA thioesterase II -
ND446_RS11955 (ND446_11955) 2637671..2638960 - 1290 WP_234055581.1 ammonium transporter AmtB -
ND446_RS11960 (ND446_11960) 2638999..2639337 - 339 WP_007886947.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T247779 WP_038243726.1 NZ_CP098694:2634989-2635192 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT247779 WP_004718732.1 NZ_CP098694:2634569-2634937 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References