Detailed information of TA system TA024777

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 889826..890466
• Replicon: chromosome
• Accession: NC_014212
• Organism: Meiothermus silvanus DSM 9946

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D7BC14
• Locus tag: MESIL_RS04560
• Protein ID: WP_013157395.1
• Coordinates: 890071..890466 (+)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D7BC13
• Locus tag: MESIL_RS04555
• Protein ID: WP_013157394.1
• Coordinates: 889826..890074 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MESIL_RS04535	886226..886762	+	537	WP_041653055.1	sigma-70 family RNA polymerase sigma factor	-
MESIL_RS04540	886759..887403	+	645	WP_013157391.1	anti-sigma factor	-
MESIL_RS04545	887530..888648	+	1119	WP_013157392.1	M20 family metallopeptidase	-
MESIL_RS04550	888723..889802	+	1080	WP_013157393.1	integrase core domain-containing protein	-
MESIL_RS04555	889826..890074	+	249	WP_013157394.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
MESIL_RS04560	890071..890466	+	396	WP_013157395.1	type II toxin-antitoxin system VapC family toxin	Toxin
MESIL_RS04565	890463..890942	+	480	WP_013157396.1	YbaK/EbsC family protein	-
MESIL_RS04570	891002..891286	+	285	WP_013157397.1	hypothetical protein	-
MESIL_RS04575	891401..892474	+	1074	WP_013157398.1	class II aldolase/adducin family protein	-
MESIL_RS04580	892618..893733	+	1116	WP_041653057.1	zinc-binding dehydrogenase	-
MESIL_RS19945	893785..893943	+	159	WP_013157400.1	hypothetical protein	-
MESIL_RS04585	894007..895077	+	1071	WP_013157401.1	calcium/proton exchanger	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14511.78 Da
• Isoelectric Point: 6.6416

>T24777 WP_013157395.1 NC_014212:890071-890466 [Meiothermus silvanus DSM 9946]
MKYLLHTDICIHLLRSQEVHLEPLERLTPGDVGMSAVTAGELIFGAYKSQRVEENLIAARALQEAIPVVALTTQTAEAYG
LIRSVLERKGTPIGANDLWIAAHALSLGLTLVTRNTREFSRVEGLRVEHWL

Nucleotide

• Length: 396 bp

>T24777 NC_014212:890071-890466 [Meiothermus silvanus DSM 9946]
ATGAAGTATCTGCTGCATACTGATATCTGCATCCACCTTTTGCGATCGCAGGAAGTACATCTCGAACCGCTTGAGCGCTT
AACTCCGGGCGATGTGGGGATGTCGGCAGTCACCGCGGGTGAGCTGATCTTTGGCGCATATAAGAGCCAGCGGGTAGAGG
AAAACCTGATCGCCGCTCGGGCTTTGCAAGAAGCCATTCCGGTAGTCGCACTGACGACGCAAACCGCCGAGGCCTACGGC
CTTATCCGGTCTGTGCTGGAGCGTAAAGGTACGCCTATTGGGGCCAACGATCTGTGGATCGCCGCCCATGCTCTATCCCT
TGGGCTCACCCTGGTCACCCGCAACACCCGTGAATTCAGCCGAGTCGAGGGGCTACGCGTGGAGCACTGGTTATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9436.62 Da
• Isoelectric Point: 10.0089

>AT24777 WP_013157394.1 NC_014212:889826-890074 [Meiothermus silvanus DSM 9946]
VATTKVFKSGNSQAVRIPKKFQFAEEEVEIFRRGDEIVLRPRKRSLAELIRGLPKASDDFFAEGRHDPSPQKQESLDESH
QR

Nucleotide

• Length: 249 bp

>AT24777 NC_014212:889826-890074 [Meiothermus silvanus DSM 9946]
GTGGCTACCACCAAGGTCTTCAAAAGCGGTAACTCTCAGGCAGTGCGCATTCCCAAGAAATTTCAGTTCGCCGAGGAGGA
GGTAGAAATCTTTAGACGTGGGGATGAAATCGTGCTGCGGCCCAGAAAACGCAGCTTGGCTGAGCTTATACGGGGGCTTC
CCAAAGCTTCGGATGACTTTTTCGCCGAGGGCCGCCATGATCCATCGCCCCAAAAACAGGAATCCCTAGATGAATCCCAT
CAACGATGA

Structures

Toxin

• AlphaFold DB: D7BC14

Antitoxin

• AlphaFold DB: D7BC13