Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 954109..954732 Replicon chromosome
Accession NZ_CP098691
Organism Yersinia ruckeri strain NVI-8524

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag ND441_RS04320 Protein ID WP_038243726.1
Coordinates 954109..954312 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag ND441_RS04325 Protein ID WP_004718732.1
Coordinates 954364..954732 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND441_RS04295 (ND441_04290) 949964..950302 + 339 WP_007886947.1 P-II family nitrogen regulator -
ND441_RS04300 (ND441_04295) 950341..951630 + 1290 WP_004718723.1 ammonium transporter AmtB -
ND441_RS04305 (ND441_04300) 951745..952608 - 864 WP_004718726.1 acyl-CoA thioesterase II -
ND441_RS04310 (ND441_04305) 952986..953300 - 315 WP_004718728.1 MGMT family protein -
ND441_RS04320 (ND441_04315) 954109..954312 - 204 WP_038243726.1 expression modulating protein YmoA Toxin
ND441_RS04325 (ND441_04320) 954364..954732 - 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
ND441_RS04330 (ND441_04325) 955781..955942 + 162 WP_004718735.1 hypothetical protein -
ND441_RS04335 (ND441_04330) 956061..956204 - 144 WP_004718738.1 type B 50S ribosomal protein L36 -
ND441_RS04340 (ND441_04335) 956224..956478 - 255 WP_038243728.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T247763 WP_038243726.1 NZ_CP098691:c954312-954109 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT247763 WP_004718732.1 NZ_CP098691:c954732-954364 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References