Detailed information of TA system TA024776

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 693956..694551
• Replicon: chromosome
• Accession: NC_014212
• Organism: Meiothermus silvanus DSM 9946

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D7BB60
• Locus tag: MESIL_RS03590
• Protein ID: WP_013157209.1
• Coordinates: 694210..694551 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D7BB59
• Locus tag: MESIL_RS03585
• Protein ID: WP_013157208.1
• Coordinates: 693956..694210 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MESIL_RS03565	690830..691240	+	411	WP_013157204.1	type III-A CRISPR-associated protein Csm2	-
MESIL_RS03570	691237..691914	+	678	WP_013157205.1	type III-A CRISPR-associated RAMP protein Csm3	-
MESIL_RS03575	691911..692798	+	888	WP_013157206.1	CRISPR-associated protein Csm4	-
MESIL_RS03580	692795..693925	+	1131	WP_013157207.1	type III-A CRISPR-associated RAMP protein Csm5	-
MESIL_RS03585	693956..694210	+	255	WP_013157208.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MESIL_RS03590	694210..694551	+	342	WP_013157209.1	type II toxin-antitoxin system VapC family toxin	Toxin
MESIL_RS03595	694548..695351	+	804	WP_013157210.1	CRISPR-associated endoribonuclease Cas6	-
MESIL_RS03600	695290..696690	+	1401	WP_013157211.1	TIGR02710 family CRISPR-associated protein	-
MESIL_RS03605	696687..697658	+	972	WP_013157212.1	CRISPR-associated endonuclease Cas1	-
MESIL_RS03610	697660..697935	+	276	WP_013157213.1	CRISPR-associated endonuclease Cas2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-110)

Antitoxin

• Antitoxin VapB-like (1-79)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12313.32 Da
• Isoelectric Point: 7.3579

>T24776 WP_013157209.1 NC_014212:694210-694551 [Meiothermus silvanus DSM 9946]
MVLGSSVLLHILFREPGYPEVARKLNGASQLLVGAPTLVETAMVLIHREGDTQLLVLEDFLRRLRVESAFRRFGKGRHPA
ALNLGDCLSYAVAKVSGLPLAYVGDDFAHTDLA

Nucleotide

• Length: 342 bp

>T24776 NC_014212:694210-694551 [Meiothermus silvanus DSM 9946]
ATGGTGCTGGGCAGCTCGGTGCTGCTGCATATTCTTTTCCGCGAGCCGGGTTACCCGGAGGTTGCGCGCAAGCTGAACGG
GGCTTCGCAGCTTTTGGTAGGGGCTCCAACCCTAGTCGAAACGGCCATGGTGCTGATTCATCGGGAAGGTGATACGCAGT
TACTCGTACTGGAAGACTTTTTGCGCCGCCTCCGGGTAGAATCGGCTTTCCGGCGCTTTGGCAAGGGCCGCCACCCCGCG
GCCCTCAACCTTGGCGACTGCCTGAGTTACGCGGTGGCCAAGGTAAGCGGCCTGCCCCTGGCCTACGTGGGCGACGACTT
CGCCCATACTGACCTGGCATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9525.98 Da
• Isoelectric Point: 4.7898

>AT24776 WP_013157208.1 NC_014212:693956-694210 [Meiothermus silvanus DSM 9946]
MALTVKNLEVECLAEEVACLAGETKTEAIRKALLERKARLARPERPRSEVIEEFLRDMQDLLPKGRRPTKGEEEEILGFG
PEGY

Nucleotide

• Length: 255 bp

>AT24776 NC_014212:693956-694210 [Meiothermus silvanus DSM 9946]
ATGGCCCTCACCGTCAAAAACCTCGAGGTCGAGTGCCTGGCCGAGGAAGTAGCCTGCCTGGCGGGCGAGACCAAGACCGA
GGCCATCCGCAAGGCCCTTTTGGAGCGCAAGGCCCGGCTGGCCCGCCCCGAGCGCCCGCGCAGCGAGGTCATCGAGGAGT
TTCTGCGTGATATGCAAGACTTACTGCCCAAGGGCCGCCGTCCTACTAAAGGAGAAGAGGAAGAGATCCTGGGCTTTGGC
CCGGAGGGCTACTGA

Structures

Toxin

• AlphaFold DB: D7BB60

Antitoxin

• AlphaFold DB: D7BB59