Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5657512..5658076 Replicon chromosome
Accession NZ_CP098609
Organism Streptomyces filamentosus strain L30

Toxin (Protein)


Gene name mazF Uniprot ID V6UJ86
Locus tag K7395_RS25170 Protein ID WP_006124458.1
Coordinates 5657729..5658076 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W9FME8
Locus tag K7395_RS25165 Protein ID WP_006124459.1
Coordinates 5657512..5657742 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7395_RS25140 (K7395_25140) 5652583..5653125 - 543 WP_010070705.1 hypothetical protein -
K7395_RS25145 (K7395_25145) 5653232..5653867 - 636 WP_010070704.1 ABC transporter ATP-binding protein -
K7395_RS25150 (K7395_25150) 5653866..5654162 + 297 WP_010070703.1 hypothetical protein -
K7395_RS25155 (K7395_25155) 5654256..5656832 - 2577 WP_006124461.1 aminopeptidase N -
K7395_RS25160 (K7395_25160) 5656957..5657457 + 501 WP_006124460.1 DUF1203 domain-containing protein -
K7395_RS25165 (K7395_25165) 5657512..5657742 + 231 WP_006124459.1 hypothetical protein Antitoxin
K7395_RS25170 (K7395_25170) 5657729..5658076 + 348 WP_006124458.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
K7395_RS25175 (K7395_25175) 5658158..5659186 - 1029 WP_006124457.1 aspartate-semialdehyde dehydrogenase -
K7395_RS25180 (K7395_25180) 5659457..5662765 - 3309 WP_199781644.1 S8 family serine peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12803.83 Da        Isoelectric Point: 11.2356

>T247751 WP_006124458.1 NZ_CP098609:5657729-5658076 [Streptomyces filamentosus]
MRRGDIYLIDFEPVRGSEANKARPALIVSNDGANATVERLERGVLTVVPLTSNTARVFPFQVLLPADECRLAVDSKAQCE
QVRAVSPQRLKRRIGSVPRRRMADVDAALRRHLAL

Download         Length: 348 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8285.03 Da        Isoelectric Point: 3.9251

>AT247751 WP_006124459.1 NZ_CP098609:5657512-5657742 [Streptomyces filamentosus]
MKISVSLPQEDVDFVDAYAAANAAESRSAVIQAAIELLRTSRLESEYEAAFAEWDKSEDAAFWDRATGDGLTDAAR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y6HI13

Antitoxin

Source ID Structure
AlphaFold DB A0A1A9D4H7

References